Set against the vibrant backdrop of Atlanta, Scream features a brand new cast of characters destined to fall prey to the mysterious killer known as "Ghostface". The series centers on Deion Elliot, a local star running back whose tragic past comes back to haunt him and threaten his hard-earned plans for his future...and the lives of his unlikely group of friends.

Season 2 of Scream picks up with Emma's return to Lakewood after several months at a retreat, where she tried to recover from the horrors of last season. Everyone is walking on eggshells around her, questioning whether she has truly gotten over the Killer's crimes. Meanwhile, Audrey is hiding her connection to the Killer, but is getting harassed by someone who knows the truth. Brooke and Jake are also keeping secrets - they are hiding a budding romance from Mayor Maddox. And, Noah is getting closer and closer to the truth about the season 1 murders. Lakewood's murderous past, both recent and distant, are once again brought to focus - with this Killer's psychotic mind-game intent on bringing Lakewood's heroes down in a storm of betrayal and bloodshed.