Lovesick follows the intense affair between two people whose lives unexpectedly intertwine. Annika, a renowned breast cancer surgeon, has just received her own cancer diagnosis. Her new patient, Nate, is a promising politician. The series explores their interwoven lives, delving into themes of love, sex, illness, death, family, children, health, medicine, and the meaning of life — all while Annika is simultaneously undergoing breast cancer treatment.