Susan Cushing asks Holmes' help in solving the disappearance of her sister Mary Browner, but it doesn't seem Holmes' type of case until he is told of a Christmas present's grisly contents.

Mycroft investigates when the Mazarin Stone is stolen from a museum, and Watson deals with the promise of a large inheritance if a third person with the surname of Garrideb can be found.

Mrs. Hudson asks Holmes to help her friend with a lodger who insists on nobody entering his room, and his secret past is uncovered.

Holmes and Mycroft investigate the murder of a professor's assistant who died clutching a woman's pince-nez.

A man dies of a mysterious tropical disease on which his cousin, his heir, is the sole authority.

After her grandson's death, an old woman consults Holmes, after refusing a strange offer to buy her house including all its contents.