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Rare Mangalitsa pig breeder Lisa is worried about her boar Hal, that has developed a large lump on its neck. Later, a famous client brings his dog to the practice, and Matt is in unchartered waters as he heads to a local college to operate on one of their fish.
Peter has to deal with the most overgrown tortoise beak he has ever seen, and Julian treats a Vizsla puppy that has eaten a washing up-sponge for the second time. Meanwhile, David rushes out to a local farm where a ewe has suffered an unusual, life-threatening prolapse.
Peter heads up Sutton Bank for a lambing with a view. But there's no time to admire it because, when he arrives, farmers Craig and Liz have been struggling for a while. The lamb is stuck, but with its legs already out, it's too late for a C-section. At the practice in Thirsk, Julian meets a pug with an unusual problem to match her unusual name. Runtleigh has a painful, prolapsed eyeball, which is bulging, and the team rush her straight into surgery. Rohin meets Juliet — but it's no romantic tale. The young heifer has a large, unpleasant tumour like nothing he's never seen before. He needs to remove it and send it to the lab to find out if it's malignant. Meanwhile, Peter has a more pleasant cow conundrum — working out how many cows are pregnant thanks to big bull Cyril. And he shows graduate vet Hannah the ropes. Julian tries to conquer his fears when nurse Natalie brings in some of her exotic pets. Unlike his colleagues, he isn't keen on getting close to the snakes or the tarantula. And Matt's with some rhinos — the Leeds Rhinos rugby league team! His dad Alan played professionally for Leeds and Great Britain, and they take a trip to Headingley to watch a match, while comparing this most physical of sports to Matt tackling sheep and cows.
Peter rushes a pregnant husky into surgery, hoping he can deliver some live puppies, but he fears it might be too late to save the entire litter. Meanwhile, Julian's old friend Rodney arrives at his practice in Thirsk with one of his lambs with a badly broken leg, and Matt treats a very poorly cow called Matilda.
Matt responds to an urgent call from a 16-year-old farmer who is worried about his pregnant ewe, which has been struggling to give birth. Peter takes young vet Hannah to meet a huge bull called Cyril. He needs a pedicure, but doesn't seem too keen on the idea and when Peter and his apprentice are finally able to get started, the clock is ticking and nerves are jangling, because they know that the big fella might wake up at any moment.
A three-legged sheep called Star might be given a new lease on life with a prosthetic leg, but the rare procedure proves to be far from straightforward. Meanwhile, Julian meets Teddy, a very special 10-month-old dachshund and his owner Kerry, who believes Teddy saved her life when she went into cardiac arrest.
Matt needs to perform an emergency C-section on a cow struggling to deliver her calf. Elsewhere, Julian meets a unique sheep called Cliff, and Peter treats a French bulldog puppy called Blue with a large lump on his eye.
A three-week-old orphaned lamb with a swollen leg is brought into the practice to see Peter, and a greyhound with a badly broken leg requires complex surgery. Elsewhere, Julian pays a visit to Jackie as one of her alpacas has a large lump on its lip that ma need operating on.
Matt rushes to a local cattle farm to help Tilly the cow give birth. Elsewhere, Mike and Rebecca have an amorous pony, who needs an appointment with Peter, and Julian operates on a young girl's poorly guinea pig, but he is shocked by what he finds.
The Yorkshire Vet returns to follow all the drama, laughter and tears as a group of town and country vets, at four different practices across the county, help animals of all kinds. Christopher Timothy, who once played the world's most famous vet, James Herriot, provides the series narration.
Peter Wright, who was trained in Thirsk by Herriot himself, has more than 40 years' experience treating all kinds of animals. After leaving Skeldale Veterinary Centre, his old boss's original practice, he now works out of Grace Lane Vets in Kirkbymoorside, on the edge of the moors in North Yorkshire. Meanwhile, Julian Norton, Peter's former partner at Skeldale, has opened a practice back in Thirsk, which he runs alongside his wife, Anne. Julian is also a partner at Sandbeck Veterinary Centre in Wetherby, just across Yorkshire.
Following in their footsteps in upholding the Herriot ethos are a team of young vets at the Donaldson's practice in West Yorkshire. They include Matt Smith, Shona Searson, David Melleney and Rohin Aojula. Although they are based at a state-of-the-art animal hospital in Huddersfield, Donaldson's is another traditional mixed practice – their work involves caring for farm animals, wildlife and popular pets as well as some that are more exotic. The vets also encounter all kinds of colourful characters, from children to kindly old ladies to larger-than-life, straight-talking farmers.
Yorkshire is the series' other leading character. As we follow the vets to more remote farm locations, the countryside provides a stunning, ever-changing backdrop. And whatever the weather, they continue the Herriot tradition – treating all creatures great and small.