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The series concludes with an episode focusing on births and new beginnings. While delivering a calf, Julian also helps a new graduate to begin her veterinary career. At the Boroughbridge surgery, nurse Sally waits to discover if a labrador impregnated by her own dog has successfully conceived, and hopes to be able to take one of the litter home when they are born. Peter Wright is more concerned with preventing pregnancies, and has four cats to castrate in one day before they can go to new homes.
Peter looks back on the highs and lows of his veterinary career. He returns to his childhood home for the first time in 50 years and visiting his former teachers from primary school to sixth form, who reveal the events that inspired his medical career. He also looks back on his experiences as a work experience student for Alf Wight, also known to the world as James Herriot.
Peter operates on Wesley, a greedy terrier that has taken its food obsession too far and eaten an oven glove. Julian makes the difficult decision to remove the eye of Patch the rabbit, but an unexpected lump raises further concerns. Julian is then called out to help a ewe that is struggling to give birth to a large lamb. A makeshift operating theatre is set up in the barn, where he performs an emergency caesarean section, hoping to save both mother and baby.
Peter heads to a neighbour's farm hoping he can save the life of a seriously ill sheep, whose infected foot has become infested with maggots. Cocker Spaniel Paddy has an unusual hernia which is stopping it going to the toilet, and if Julian can't fix the problem it could lead to serious complications. With Katy on hand to help, there's a dirty job to do before they can begin the complex operation.
A rare cattle breeder fears for the life of his favourite cow, which has been diagnosed with cancer and will need major surgery to have any chance of survival. A rottweiler puppy becomes seriously ill after eating 15 stones, a ram undergoes fertility tests, and a donkey has a problem with one of its legs. Plus, receptionist Sylvia leaves the Skeldale practice, so the staff prepares a special surprise for her.
Peter faces a struggle to save a baby alpaca that was born prematurely during a storm, and Julian performs a delicate eye operation on a labrador preparing for a dog show. A wallaby dies at a local visitor farm, raising concerns that its joey will not survive without its mother's milk and pouch. A newborn lamb suffers a potentially fatal injury, and a rabbit named Boris needs to be castrated if it is to stay in its new home.
Julian treats a lhasa apso with a mouth tumour which other vets have given up on, and comes up with an alternative course of action to save the dog's life. He also locks horns with an aggressive ram that has a sore eye. Over in Thirsk, Peter treats a Shetland pony with a painful foot condition and a cow with a prolapsed uterus.
Peter gets an emergency call from sheep farmer Clive, whose ewe has gone into labour, but the lambs are tangled up inside their mother. One arrives safely but the second isn't breathing, and Peter's skills are put to the test when he realises there is a third lamb still to come. In Boroughbridge, Julian and Anne operate on a dog with a tumour in its chest.
The Yorkshire Vet returns to follow all the drama, laughter and tears as a group of town and country vets, at four different practices across the county, help animals of all kinds. Christopher Timothy, who once played the world's most famous vet, James Herriot, provides the series narration.
Peter Wright, who was trained in Thirsk by Herriot himself, has more than 40 years' experience treating all kinds of animals. After leaving Skeldale Veterinary Centre, his old boss's original practice, he now works out of Grace Lane Vets in Kirkbymoorside, on the edge of the moors in North Yorkshire. Meanwhile, Julian Norton, Peter's former partner at Skeldale, has opened a practice back in Thirsk, which he runs alongside his wife, Anne. Julian is also a partner at Sandbeck Veterinary Centre in Wetherby, just across Yorkshire.
Following in their footsteps in upholding the Herriot ethos are a team of young vets at the Donaldson's practice in West Yorkshire. They include Matt Smith, Shona Searson, David Melleney and Rohin Aojula. Although they are based at a state-of-the-art animal hospital in Huddersfield, Donaldson's is another traditional mixed practice – their work involves caring for farm animals, wildlife and popular pets as well as some that are more exotic. The vets also encounter all kinds of colourful characters, from children to kindly old ladies to larger-than-life, straight-talking farmers.
Yorkshire is the series' other leading character. As we follow the vets to more remote farm locations, the countryside provides a stunning, ever-changing backdrop. And whatever the weather, they continue the Herriot tradition – treating all creatures great and small.