The 49ers and Lions meet in a rematch of the 2023-24 NFC championship game, won by San Francisco 34-31. Detroit is vying for the NFC North title and the No. 1 seed in the playoffs. Entering Week 17, the Lions led the NFL with 32.9 points per outing.

The Packers will appear on Monday Night Football for the 32nd consecutive season – the longest current streak among all NFL teams.

The Raiders will host a Monday Night Football game for the seventh year in a row.

Desperate teams come together in Big D as the Cowboys (5-7) host the Bengals (4-8). Dallas won its last two games to remain in the NFC playoff conversation. Cincinnati has plummeted down the AFC wild-card standings with three straight losses.

Denver will host their first Monday Night Football game since the 2021 season.

Ravens' head coach John Harbaugh will take on his brother, Chargers' head coach, Jim Harbaugh, in the third edition of the Harbaugh Bowl. John and the Ravens are 2-0 against Jim with the second win coming in Super Bowl XLVII.

Houston wide receiver Stefon Diggs will take on his younger brother, Dallas cornerback Trevon Diggs, for the first time in their NFL careers – both as active roster members.

After winning Super Bowl LVI with the Los Angeles Rams, Miami's Jalen Ramsey and Odell Beckham Jr. return to Southern California for the first time to play the Rams.

Tampa Bay's Baker Mayfield will look for his first career win against Kansas City; in his previous starts against the Chiefs (both with Cleveland), Mayfield has a 71.43 completion percentage — his highest against any team.

The Steelers are 13-1 on MNF in the past ten years – the most wins of any team.

The last meeting between the New York Giants and the Steelers occurred on MNF in 2020 when the Steelers beat the Giants (26-16).

The reigning league MVP, Lamar Jackson, will take on the NFC South Champion Buccaneers for the second time in his career on Monday Night Football – the Ravens won the teams' first meeting, 27-22, in 2022.

The AFC East rivals will play on Monday Night Football for the second year in a row following their highly anticipated Week 1 matchup in 2023.

Through seven Monday Night Football starts, Kansas City quarterback Patrick Mahomes has 19 touchdown passes – tied for the most with Dan Marino in the same time period.

Miami will host Tennessee on Monday Night Football for the second year in a row; last season, the Titans recorded an improbable rally in the final three minutes of the fourth quarter to beat the Dolphins (28-27).

Buffalo will host a Monday Night Football game for the fourth consecutive season.

Through the first seven Monday Night Football starts of his career; Bills quarterback Josh Allen has 18 passing touchdowns, third behind only Hall of Famer Dan Marino and Mahomes who both have 19 in the same time period.

The Eagles are 11-6 on Monday Night Football in the past ten years — the second most wins of any team.

Kirk Cousins will make his Monday Night Football debut as a member of the Falcons.

Aaron Rodgers and the Jets will kick off their season on Monday Night Football for the second year in a row.

Rodgers heads to Northern California to play against his hometown team for the first time since 2021, when he was a member of the Packers.

The annual Hall of Fame Game from Canton, Ohio.

This matchup between rookie-quarterback Caleb Williams' Bears and the reigning Offensive Rookie of the Year C.J. Stroud's Texans will be the first opportunity for fans to see NFL game-action ahead of the 2024 season.