Aaron Rodgers and the Packers try to snap a three-game slide against the Cardinals. Rodgers is 2-4 versus Arizona. The Cardinals won the last meeting 20-17 on Dec. 2, 2018, six days before Arizona's Kyler Murray won the Heisman while at Oklahoma.

Week 6 begins when Tom Brady and the defending Super Bowl champion Buccaneers visit the Eagles. Brady is 5-2 versus Philadelphia, including a Super Bowl win and loss. The 44-year-old has 15 touchdowns and two interceptions versus the Eagles.

Matthew Stafford gets his first taste of this NFC West rivalry as the Rams visit the Seahawks. Los Angeles won two of three meetings last season capped by a 30-20 triumph in the NFC wild-card round. Stafford was 1-3 versus Seattle while with Detroit.

New York seeks its sixth straight win over Washington in a rivalry that began in 1932. The Giants lead the series 105-69-4. New York swept the two 2020 meetings by a combined four points, and has won the last three get-togethers by a total of 10.