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Surgeons take on major trauma operations at Birmingham's Queen Elizabeth Hospital. They have just minutes to save a woman with a life-threatening bleed on her brain.
A surgeon performs the most complex operation in his field: removing a woman's oesophagus and using her own stomach to replace it. Another team tackles a hard-to-reach tumour.
At Birmingham Children's Hospital, surgeons must transplant a kidney from a father to his two-year-old son, while a three-year-old girl needs a life-changing heart procedure.
Surgeons at Birmingham's Queen Elizabeth Hospital carry out radical operations to help change patients' lives, including the hospital's largest ever removal of excess tissue.
Maxillofacial surgeon Tim Martin operates on a woman with a disease so rare, he is thought to be the first in the UK to attempt the procedure.
Cameras return to the operating theatres of Birmingham's Queen Elizabeth Hospital, and reveal what goes on during procedures that test the limits of what is possible.
The new series will be filmed in Edinburgh and The Lothians at some of the region's leading centres of medical excellence - NHS Lothian's The Royal Infirmary, Western General and St. Johns.
With unprecedented access to surgeons, anaesthetists, theatre staff and patients, the series will once again offer a unique insight into to the innovative and experimental surgeries taking place on the frontline of medical science.
Documentary series going beyond the theatre doors of Queen Elizabeth Hospital Birmingham, where surgeons push medical boundaries to the limits.