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Surgeons drain all of their patient's blood from his body to replace damaged arteries. A patient's fertility is at risk without a complex operation to remove diseased bowel.
A surgeon must remove part of his patient's tongue and reconstruct it to save her from an aggressive cancer, and surgeons perform a rare simultaneous pancreas and kidney transplant.
Surgeons face a difficult dilemma in the middle of a life-saving bile duct cancer operation. A chest sarcoma proves more challenging than expected, with no room for error.
One patient's rare penis cancer requires a partial amputation, and another patient with severe endometriosis must have a huge cyst and a damaged kidney removed.
The new series will be filmed in Edinburgh and The Lothians at some of the region's leading centres of medical excellence - NHS Lothian's The Royal Infirmary, Western General and St. Johns.
With unprecedented access to surgeons, anaesthetists, theatre staff and patients, the series will once again offer a unique insight into to the innovative and experimental surgeries taking place on the frontline of medical science.
Documentary series going beyond the theatre doors of Queen Elizabeth Hospital Birmingham, where surgeons push medical boundaries to the limits.