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Mannix helps out a friend who works at a carnival and whose life has been threatened several times.
A young horsewoman disappears, and everyone Mannix talks to say that she never arrived at the country fair where she supposedly disappeared.
An alleged crook, Armitage, is murdered on air while participating in a telephone interview. A woman is caught fleeing the scene and arrested, and her twin sister hires Mannix to prove her innocent.
A private eye and friend of Mannix's turn up dead, apparently drowned. But Mannix believes there's more involved... as do the two men who abduct Peggy and Toby and demand Mannix turn the evidence over to him.
Mannix must decipher the fantasies of an emotionally-disturbed 9-year-old girl who witnesses the death of her doctor and the theft of $150,000 in bearer bonds.
Someone hires three unrelated hitmen to take out Mannix. He survives the attempts and travels to Nevada to find the person responsible.
An executive's wife hires Mannix to find out who is trying to kill her. The only clue: a locket with the word "Sylvia" written on it.
Mannix goes undercover as a sailor when a bank hires him to find a missing man.
Mannix hunts down a secretary who claims that her boss attempted to kill his estranged wife. The boss says that she misinterpreted what she saw, and the PI has to figure out the truth.
A pharmacy robber's wife hires Mannix to clear her husband after he robs the same pharmacy twice.
An executive hires Mannix to track down a blackmailer preying on the executive's wife.. and then denies ever talking to Mannix.
Mannix claims that Gail's son Toby is his client to investigate her dead ex-husband, who has been implicated in a series of robberies.
Peggy asks Mannix to help her old friend, whose son Cap is turning to crime.
A horse owner hires Mannix to find his prize race horse... which apparently went down in a plane crash.
A supposedly murdered man lets his killer belief that he's dead... and hires Mannix to find the person responsible.
An assassin's bullet grazes Mannix and renders him blind, and he trains to overcome his condition and defend himself for the killer's return.
A man hires Mannix to track down a pedestrian he may have ran over with his car. But the only witness claims nothing happened, and men threaten Mannix figuring that he killed the pedestrian.
The private secretary of a murdered PI comes to Mannix for help. She doesn't remember much about her boss' cases, but men are trying to kill her anyway.
Ellen Barton hires Mannix to determine that her husband's death in a scuba-diving accident was no accident.
Three men claiming to be escaped convicts come after Mannix's new client, claiming that they want the money in a briefcase she has. But Mannix figures there's more going on.
An old friend from Mannix' college days asks him to clear the name of a doctor who lost his medical license... and who actively fights Mannix's efforts to clear him.
A studio exec hires Mannix to protect an obnoxious movie star who isn't taking murder attempts against him seriously.
Joe's old flame Jean McBride asks Mannix to return to their hometown and clear her husband of a murder charge.
Mannix's mentor is thrown to his death from a high-rise apartment, and the primary suspect asks Mannix to find a woman who can clear his name.
Mannix launches a double-edged search for Brad Turner and Jimmy Whitewing, two friends of Peggy's, who are wrongly accused of murder, and for the real killer who can only be linked to the crime by a dancer. Brad and Jimmy seek refuge in Peggy's apartment, but flee when Mannix offers to help them under the condition they tell their story to the police.