During a car race, Mannix crashes due to hallucinations. He's taken to a private hospital where his condition worsens... and a nurse tells him that the doctor is drugging him.

Crooks hire an imposter to pose as Mannix, who ends up kidnapped while the imposter takes his place.

Lt. Larry Gifford hires Mannix to clear his name when he accidentally shoots and kills the man who killed Gifford's partner years before.

Mannix tries to determine why Vince Logan, a singer and friend of Peggy's, fled the police when they tried to question him about a property damage claim and was subsequently shot trying to flee.

A man is accused of killing his wife when he tracked her down with the man he claims that she was having an affair with. But another PI who was working the case tells Mannix that the wife never had an affair.

A young mobster hires Mannix to track his unfaithful wife. When someone guns down the mobster, his family figures that Mannix set him up.

A toy manufacturer hires Mannix to quietly find out who tried to kill him.

A woman hires Mannix to find her missing husband. But when the PI does and the man is dead, the wife says that he's not her husband.

A CEO hires Mannix to find the plans for a miniature computer... but doesn't tell the PI that a letter with the plans has damaging information against him, and he plans to have Mannix killed once the detective finds them.

A comedian is tied in with a private eye's murder.

A dying man confesses to a nun that an inmate is innocent, but the inmate insists that he's guilty.

Before he's murdered, a PI sends a letter to Mannix, and criminals will do anything to get it.

Mannix wonders why he has been simultaneously fired from separate cases.

Mannix's former commanding officer asks him to buy blackmail of him with his mistress. But the PI soon suspects that there's more to the story.

A friend of Mannix's dies after killing another man and holding a woman hostage. The PI tries to unravel his friend's dying words about "button" and "General D".

A mobster has his men kidnap Peggy and gives Mannix 72 hours to find a stool pigeon in his organization... or Peggy dies.

Mannix suspects that an old friend, now a New York detective, is involved with attempts on the life of a fugitive in his custody.

A boys' baseball team coach goes missing, and the boys hire Mannix to find him.

A woman hires Mannix under false pretenses claiming that a missing man is her brother.... when he's actually a journalist who someone wants dead.

A woman hires Mannix to protect her and the manuscript she inherited from her father, but the PI soon has doubts when the woman disappears.

Mannix returns to his hometown and finds himself embroiled in a murder case.

Mannix is jogging on the beach and sees two men attack a women at her home. The problem is that the crime Mannix describes happened a year ago.

While on vacation, Mannix befriends two young women. One turns up dead, but Mannix figures the other one was the intended target.

A woman kills an intruder who she claims is blackmailing her, and hires Mannix to prove it.