Loki Season 2 picks up in the aftermath of the shocking season finale when Loki finds himself in a battle for the soul of the Time Variance Authority. Along with Mobius, Hunter B-15 and a team of new and returning characters, Loki navigates an ever-expanding and increasingly dangerous multiverse in search of Sylvie, Judge Renslayer, Miss Minutes and the truth of what it means to possess free will and glorious purpose.

《复仇者联盟4》中众复仇者为集齐无限宝石挽回灭霸响指后烁灭的人们，穿越回2012年的纽约大战。

由于钢铁侠的不慎将宇宙魔方落于洛基之手，洛基得以逃脱，但洛基的行为打乱了单一“神圣时间线”，时间变异管理局TVA出动将洛基缉拿。

来到TVA的洛基与莫比乌斯探员共同追击时间犯（variant）另一个洛基（希尔维，女洛基），洛基在与女洛基的相处中得知TVA是一个骗局后，二者共同走上了探索最终真相之路。