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The CSIs discover that several suspects in a woman's murder are members of a bizarre UFO club who believe that shape-shifting reptile-like aliens have mated with humans for centuries as a means of conquering the human race.
In their attempt to identify the murderer of a has-been boxer who lived among a group of prostitutes who detested him, the CSIs must establish which of several life-threatening acts against him in one night actually killed him.
Sara's uneasy about Grissom being reunited with Lady Heather during the CSI's investigation of her attempted murder by a client she refuses to name.