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Cache of missing chips from a closed down casino turn up in Vegas and a string of murders follow, leading Langston to use deadly force for the first time in his career as a CSl.
The CSIs are on the case when a member of a motorcycle gang is murdered at a local biker bar.
An unexplained illness that is affecting random citizens of Las Vegas baffles the CSIs.
Catherine revisits one of the very first cases she worked as a CSI when the convicted felon in the murder claims the verdict was based on faulty evidence.
When Hodges and Wendy run into each other at a science fiction convention for one of their favorite classic television shows, they end up investigating the murder of one of their beloved actors.
Nick's case of a deceased skydiver takes an interesting turn when Catherine discovers there may be a connection between the skydiver and a mysterious double murder case.
Langston is shocked when his former student is found murdered and becomes the focus of a CSI investigation into the world of Mexican wrestling.
Langston and Riley are taken hostage during the aftermath of a shootout in an usually calm Las Vegas community.
When the CSIs are called to a murder scene at a familiar motel, Nick is thrown for a loop as he pieces together three separate murder investigations that all took place at the same establishment over the course of a year.
The CSIs are called to three different crime scenes in one night that are seemingly unrelated, but each case's forensic evidence reveals a common link.
While Langston testifies in the trial of a respected Congressman, new evidence sends the CSIs back to the lab to reopen the investigation.
Langston and Nick are called to investigate a murder at a fast food restaurant and have quite a task ahead of them when they discover that much of the evidence is coated in cooking oil.
When an FBI agent who was working undercover is found brutally murdered, the CSI team is called in to assist the victim's partner in finding the killer.
The first day on the job for Dr. Langston turns from bad to worse when a simple burglary case quickly overlaps with a complicated arson and homicide case.
The CSI team is shocked and saddened when, after working with Dr. Raymond Langston on the "Dick & Jane" murders, Grissom announces that his time as a CSI has come to an end and offers Langston a permanent position on the CSI team.
When a new murder leads to a connection with an infamous serial killer, Grissom secretly joins the class of well-known criminal pathologist Dr. Raymond Langston, to gain access to the killer and get a crack in the case.
When a popular young singer is found dead outside an infamous Las Vegas nightclub, the CSI team uncovers a link between the present day crime and a murder from over 50 years ago.
The prime suspect in a murder case from 12 years earlier comes to the forefront of a new CSI investigation.
After a shooting involving a young boy occurs right in the middle of Koreatown, none of the witnesses will speak to the CSI team investigating the case.
When the CSI team investigates a case involving the world of domination, Grissom pays a visit to Lady Heather to help find some answers.
During the course of an investigation, the CSIs discover that their victim, a young woman who was murdered and found with several different blood types in her system, is the daughter of a wanted criminal.
When a series of victims are found deceased seemingly in the middle of everyday activities, the CSIs must determine what is causing them to remain upright after death.
Hypnotist who uses her powers of persuasion to rob banks becomes the prime suspect in a murder investigation.
The CSI team comes together after Warrick is shot in a Las Vegas alleyway,.
After 15 seasons and more than 300 episodes, the CSI team of D.B. Russell, Sara Sidle, Greg Sanders, Dr. Albert Robbins, David Phillips, David Hodges, Morgan Brody and Henry Andrews welcome back Gil Grissom, Catherine Willows and Jim Brass for their final case, when they investigate a catastrophic event that paralyzes all of Las Vegas. Russell and Sidle will make decisions regarding their crime-fighting careers, and the return of Lady Heather will create controversy one last time between Grissom and Sidle.