Team Rocket receives orders from Giovanni to take a vacation, which apparently applies to all Team Rocket members, but while they're taking things easy in the Sinnoh Region Resort Area Matori and her Elite Team swoop in and start snatching up Pokémon! Now Jessie, James, Meowth and Wobbuffet have to work with Ash and Go, who are also in Sinnoh, to stop Matori without the two trainers finding out who they are and without headquarters finding out that they are violating their orders.

All the food in the Sakuragi Park has disappeared, and all the Pokémon there are starting to fight out of hunger. Ash and Go decide to stake out the park overnight to catch the culprit.

Ash & Go have head to Littleroot Town in Hoenn to investigate the Beautifly migration, which only happens once a year. During this, Go wants to get another Wurmple and calls to Raboot, but Raboot is disinterested. Later, Raboot sneaks out of the Pokémon Center. Where is it going?

Go has taken an interest in Pokémon eggs, as he has never seen one so he and Ash go searching for one. In their search, they come across an egg at the Pokémon Center. This egg has been passed from place to place without it hatching. However, Nurse Joy decides to entrust the egg to Ash. Will Ash be able to get the egg to hatch?

Professor Sakuragi is holding a Pokémon Orienteering event at his laboratory where kids will go through various spots to look for Pokémon. Ash and Go have both been chosen a leaders to guide the children around. Ash gets really focused on the battle part of the event while Go focuses on catching them, furthering their dreams. However, before too long Lugia appears.

Team Rocket have gone to a movie set in order to get a movie role for Jessie. However, when there, a director gets mad at Ditto, a Pokémon that has a role in the movie, as it is struggling with its transforming. Ditto runs away from the set and ends up with Team Rocket who decide to help it become a skilled actor. Meanwhile, Ash & Go have been called upon in order to find the Ditto. Will they get the Ditto back or will it stay with Team Rocket?

Ash intended to battle the World Champion, Leon again, so he has entered the Pokémon World Championships. To qualify for the final few, he has to battle other trainers who are qualified. To start with, he will face Visquez, the deputy Gym Leader at Vermilion City Gym while Lt. Surge is away. Each trainer uses two Pokémon with Ash picking Pikachu and Gengar and Visquez picking Electrode and Raichu. Will Ash manage to win?

As Pikachu & Scorbunny are practicing battles, Go's Darmanitan comes over to try and get Scorbunny to use a Fire-type move. Scorbunny tries to use Ember but it doesn't go well and it gers made fun of. Annoyed, Scorbunny starts practicing the move, with Go not wanting to help as Go feels Scorbunny can battle just fine with other moves. This causes friction and Go & Scorbunny start to fight... Will they make up and will Scorbunny learn to use Fire-type moves?

Strange phenomenon have been happening at Sakuragi's Laboratory lately such as rooms getting ramsacked. On hunting down the problem, Ash & Go find out that the culprit is none other than the Gengar they had encountered previously. Ash & Go both intend to catch the Gengar but Ash starts acting very weird and even almost falls down the stairs. Is Gengar responsible? Will they stop Gengar?

There are some issues at Sakuragi's laboratory. As such, Ash and Go have to return home while the systems are being fixed. Go is happy to see his parents as he hasn't seen them for a while but gets told they can't return home due to a job they have to do. Expecting as much, Go travels around town and meets a Cubone that is very sad. Go decides to help the Cubone look for the object that's missing, will he be able to find it?

The Ruins of the Titans have been discovered in the Desert Resort in Unova so Ash & Go head there to research the ruins. When they get there, they find numerous traps and eventually encounter an expedition team. With their help, they reach the end of the ruins and find a giant Golurk. Is this the titan of the ruins?

Following the Pokémon World Championships final, a wild Drednaw has mysteriously Gigantamaxed in Wyndon Stadium. Ash and Go try to stop it but Pikachu starts getting surrounded by a red light... then, after that, Ash challenges Leon to a battle. With Ash using Pikachu and Leon using Charizard, the battle is fierce. Who will win? The Alola Champion or the World Champion?

Ash & Go have gone back to Galar to watch the finals of the Pokémon World Championships, a competition that determines who is the best at Pokémon battles in the year. In the finals, Lance from Kanto and Leon from Galar face off. Ash & Go are excited waiting for the battle showcasing the Dynamax phenomenon. The battle is against the Red Gyarados Lance caught in Johto and Leon's Gigantamax Charizard. Who will win?

Unlike Ash & Go, Koharu is very unenthusiastic about Pokémon. She gets on well with the Yamper but has no interest in capturing or battling with Pokémon. She is often labelled as someone who really loves Pokémon due to her father, Professor Sakuragi, a label which bothers her. Meanwhile, a Gengar starts to cause trouble in Sakuragi's Laboratory. Will Koharu rid herself of the label and will they stop Gengar?

Ash & Go have heard of a person who got rescued by Dragonite on the news. After hearing of their interest in Dragonite, Professor Sakuragi informs them of an area where Dragonite live. Ash & Go immediately go to search for it by sea. However, on the way they are hit by a storm and run aground on the island where Dragonite live. Will they meet the rare Dragonite?

Ash & Go have heard that the Legendary Pokémon, Ho-Oh, has been sighted in Ecruteak City in Johto so head straight to Johto to find it. When there, they see a Pokémon that resembles Ho-Oh instantly but soon learn it's a fake. They discover a local boy disguised one of his Pokémon as Ho-Oh to show his grandfather the Pokémon. However, with his plan failing, he hopes to find the real Ho-Oh. Will he succeed?

At Vermilion City's port, Ash & Go find a worn out and disheartened Piplup. Taking it back to the laboratory, they're contacted by its Trainer who states that it swam there all the way from Sinnoh. Ash & Go decide to go to Sinnoh to escort Piplup back and learn of an Ice Floe Race. Will they enter?

After catching many Pokémon in Kanto, Ash decides to take Go to the Hoenn region to participate in a special battle tournament. Ash is always eager to battle and is psyched but this is the first time Go has battled as he has just realised how fun catching Pokémon is. Using his newly captured Scyther and Scorbunny, battles are tense and Ash turns up to battle with the Mr. Mime his mother owns and left to look after Ash. Who will win the tournament?

After catching Scorbunny in Galar, Go noticed that his Pokédex got filled in when he caught it, which has caused him interest in getting every Pokémon. With Ash, he travels to the forests in the Kanto region and notices a lot of Bug-type Pokémon, so he sets himself a task: Catch every Bug Pokémon from Kanto. Which Pokémon will become his partners?

Ash & Go have arrived at the Wild Area, a huge area filled with wild Pokémon. However, they soon come across a Snorlax which soon grows to massive sizes. As they came to learn about the Dynamax phenomenon, Ash & Go are excited by this. However, the Scorbunny they encountered in Wyndon has also come to the Wild Area in search of Go. Will they be able to meet again?

Ash and Goh travel to the Galar Region to investigate reports that Pokemon are growing giant-sized, meeting up along the way with a mischievous Scorbunny that seems to connect with Goh.

A bunch of Ivysaur are causing chaos throughout Vermilion City, and Professor Cerise sends Ash and Goh to investigate. While learning the cause of the trouble, they not only learn more about each other but also clash with Team Rocket, who are now using Pokéballs supplied by Giovanni and delivered by a Pelipper that arrives whenever they call it. With the help of the Ivysaur, Pikachu defeats Team Rocket and the Ivysaur evolve into Venusaur.

Ash, his mother Delia, Mr. Mime, and Professor Oak travel to Vermilion City to attend the opening of Professor Cerise's new research lab. Professor Cerise wants Goh to choose the Kanto starters, but he refused because he wants to choose Mew instead. The sudden appearance of Lugia causes Ash to meet Goh, a new Trainer with his own dream, and both of them to go on the ride of a lifetime to learn more about Lugia.

In this prequel episode, Pikachu's backstory as a Pichu, his being cared for by a Kangaskhan after falling off a cliff, and Ash's backstory when he was 6 years old missing Professor Oak's camp because he overslept and breaking the Poké Ball Clock, the events leading to his evolution into a Pikachu and eventually meeting Ash are revealed.