Bill and Mary Yoder are a happy couple, running a medical practice outside of Utica, New York. But their world collapses when Mary becomes mysteriously sick, and detectives prove that her illness was no accident.

William Walker is a prominent firefighter, living in a tight-knit Cleveland neighborhood with his new wife, Uloma. But the couple's world is shattered when William is gunned down in their driveway, causing everyone in his life to be a prime suspect.

Rob and Brenda Andrew are a devout couple, living in the Bible Belt of Oklahoma City. But their world is shattered when both of them are shot during a violent home invasion. The mastermind will prove to be closer than anyone ever imagined.

Kevin & Tabatha Bryant are a picture-perfect couple, living with their two young sons in Penfield, New York. But when Tabatha is found stabbed to death at home, a steamy affair and many double lives are revealed to the town's unsuspecting residents.

Chris Northam is an entrepreneur building his sports business in California. When he is shot in his warehouse, suspicion falls on his employees and his mistress.

When Gary and Jan Tyrrell, are murdered in their museum-type Missouri home, the tight-knit community look at those closest to the pair as their potential killer.