Bettie Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.

Chuck starts from scratch during his second year of weight-loss, discovering a promising new relationship. Paula juggles many responsibilities head at once, but is it too much to stay on track for her weight-loss goal?

Away from Dr. Nowzaradan's care, Penny has returned to Maryland believing she can make the choices to lose weight, but has she truly changed? Dating for the first time in her life, Tara continues to lose weight and is learning to balance new roles.

Olivia strives to weigh-in under 200-lbs as she lives by herself for the first time & suffers an unexpected loss. Battling a series of let downs, James fights to reach his goal of skin surgery and to live a fulfilling relationship for the first time.

During her second year of weight-loss, Zsalynn is torn between fighting her weight and fighting for her marriage. Christina lets go of the negative influences in her life and is finally able to live the life of a twenty-something.