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The search for Scylla comes to a shocking end as Sara takes a hostage, T-Bag and Gretchen have their last stand at Gate, and Michael and Lincoln come face-to-face with the General and are betrayed by one of their own.
Michael races against time and his ailing health to break into the Company headquarters to steal Scylla, but the break-in's success lies with Sucre. Gretchen dresses up for a meeting with the General and one final attempt to get the last card key. T-Bag must make a decision to leave his criminal ways for good.
Michael must hold the team together after they are betrayed by one of their own. T-Bag gets a new partner who blackmails Gretchen into finding a buyer for Scylla.
The major storyline for the fourth season is about a team recruited by Homeland Security agent Don Self to obtain the Scylla. Although the team initially believes it to be The Company's "black book," it is later revealed to contain information on an advanced renewable power cell.