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Before Evan and Paige marry, the weather puts a few obstacles in their way along with a surprise. Flashbacks reveal how Hank's own engagement party ended up creating a wedge between him and Evan.
The bachelor and bachelorette parties converge in Las Vegas where Divya's romance leads to a surprising conclusion. Evan feels guilty his cousin Owen, whose money he lost in a bad deal, comes down for the wedding. Trying to help the man's medical condition, Hank faces the effects of his own injuries and runs into an old flame.
Hank cancels his weekend plans after treating an amateur beach volleyball player who he believes may be suffering from more than just a summer bug. Meanwhile, Divya confronts her new boyfriend after a startling discovery.
Hank must travel across the globe to help an injured Dmitry. Meanwhile, Evan and Paige meet a woman claiming to be Paige's biological mother.
Hank treats an uptight student and her novelist mother, who have both fallen ill. Divya's new boyfriend asks Dr. Sacani for help; Evan helps Paige deal with a family problem.
When a famous pop star comes to the Hamptons to prepare for her new world tour, HankMed must stay on hand to treat her for more than just exhaustion. Meanwhile, Divya becomes distracted when she falls head over heels for a globe trotting polo player.
With a Polo tournament in full swing in the Hamptons, HankMed is on hand to treat a polo team owner who won't quit playing despite his condition. Also, Divya deals with the realities of dating and Evan frets about an impending meeting of the in-laws.
While HankMed treats an undercover DEA Agent, Divya and Jeremiah tend to a MMA fighter who may have gone a bit soft. Meanwhile, Hank becomes more involved with Boris' interpreter, much to Boris' chagrin.
Evan and Paige comfort a close friend who's experiencing a painful loss; Hank and Divya treat an overweight veterinarian who's in the middle of a divorce; a person attending a secret meeting at Boris' mansion falls ill.
Hank is whisked away to a secret meeting in Manhattan by Boris to help care for a stubborn Russian oligarch, and befriends their female interpreter in the process. Meanwhile, Evan and Jeremiah treat an Internet entrepreneur and Divya reconciles with her father.
HankMed treats an absent minded country club manager while Evan, with Paige's help, lands the business opportunity he's always dreamed of. Hank accepts, without prior details, to be on call by exclusive pager for Boris' latest top secret project.
Evan has difficulty managing HankMed; Hank treats a matchmaker who wants to set up both Divya and him; Boris takes steps to protect his family; Paige's party gets out of control.
Hank & Evan's father Eddie makes his return to the Hamptons and schemes to bring his boys back together. Hank has a new patient who is participating in a zombie race for charity. Evan also has a new patient, a retired biochemist with a possibly sinister past.
Hank and Evan heatedly compete for a new business opportunity. Meanwhile, Divya attempts to covertly reconcile the brothers' differences and Jill has a going away party.
When Jill's chess obsessed nephew gets kicked out of camp for fighting, Hank realizes Luke may be suffering from more than just teenage hormones. Evan courts a young, lonely heiress for his new client roster, and Divya – caught between the brothers -- faces an impossible choice.
Hank embarks on a fresh start with his medical practice and separates from his brother Evan, who also starts his own venture. As Divya attempts to reconcile the brothers, HankMed teams up once more in the face of a Hampton's emergency.