The rules have changed in the aftermath of the bloody hunt for Escobar as the DEA turns its attention to his successors: the Cali Cartel.

The Escobars cope with the challenges of life on the run. Pablo's enemies team up against him. The Search Bloc's tactics become increasingly dubious.

As drug lord Pablo Escobar rises, Colombian and U.S. law enforcement find themselves battling an enemy who will do anything to keep his empire.