Pablo's activities in prison forces the government to use extreme actions. Murphy and Peña have to deal with a problematic situation.

The hunt for Pablo seems to be over once he signs a deal with the government, but Murphy, Peña and the Calicartel have different thoughts about that.

A tragic mistake forces the government to change strategies to fight Pablo, but Pablo has bigger issues as there is danger from within his empire.

Pablo went to hiding as political tides are turning against him, but he finds a way to beat back. The CIA is finally offering their help to Peña and Murphy.

Gacha was almost caught by Peña and Carillo. Murphy tries to protect candidate Gaviria against assassins with ties to Pablo as she is in favour for extradition.

Pablo's extreme methods is almost leading to a war between drug lords, Carillo and the government. Peña tries to protect his witness Elisa.

Despite a new extradition treaty, the USA is increasing their budget to fight communism. It will create new challenges for Murphy and Peña to hunt for Pablo Escobar.

Murphy is confronted with corruption in the Colombian government once he tries to discolate Escobar's his political ambition together with his partner Peña.

The communistic radical group M-19 are counteracting the drug lords and Murphy's new partner Peña teaches him the Colombian way of law enforcement.

A Chilean drugsproducer, the chemist Cockroach, brings his product to the Colombian smuggler Pablo Escobar. DEA-Agent Steve Murphy is fighting drugs in Bogota.