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A Chilean drugsproducer, the chemist Cockroach, brings his product to the Colombian smuggler Pablo Escobar. DEA-Agent Steve Murphy is fighting drugs in Bogota.
The communistic radical group M-19 are counteracting the drug lords and Murphy's new partner Peña teaches him the Colombian way of law enforcement.
As drug lord Pablo Escobar rises, Colombian and U.S. law enforcement find themselves battling an enemy who will do anything to keep his empire.