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The communistic radical group M-19 are counteracting the drug lords and Murphy's new partner Peña teaches him the Colombian way of law enforcement.
A Chilean drugsproducer, the chemist Cockroach, brings his product to the Colombian smuggler Pablo Escobar. DEA-Agent Steve Murphy is fighting drugs in Bogota.
Murphy is confronted with corruption in the Colombian government once he tries to discolate Escobar's his political ambition together with his partner Peña.
As drug lord Pablo Escobar rises, Colombian and U.S. law enforcement find themselves battling an enemy who will do anything to keep his empire.