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House starts the year in prison, serving out a long term for his various misdeeds in Moving On. However, it turns out that he didn't even try to get a lesser sentence and took a one-year term without complaint. He blows a chance for early parole in order to prove a fellow patient's diagnosis. Although he plans to withdraw from the practice of medicine, it appears the real co-dependent relationship is between House and the hospital. With House looking at serving at least another six months, the new Dean of Medicine, Eric Foreman approaches House with an offer to return to work.
Facing a 6-month jail term and realizing that he won't be there for Wilson at the end, House finds himself examining his entire life while contemplating a dismal future without his best friend. Trapped in a burning building, House must come to terms with his life, choices, personal demons, and future.
The one-hour retrospective special looks at this groundbreaking seminal series, including the finale, interviews with the series stars and producers, unique original content, and other surprises. It aired just before the series finale Everybody Dies.
The team takes on the case of Derrick, a 19-year-old college student who had a mysterious nosebleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother's voice in his head. Meanwhile, Foreman tries a different approach with House. Wilson and House continue to come to terms with Wilson's cancer.
Over his years performing autopsies at Princeton-Plainsboro Teaching Hospital, Dr. Peter Treiber often identifies mistakes made by physicians that caused the patient's death. These observations make him question the skills of nearly all the doctors on staff, all that is, except House. When he falls ill, he demands that only House make medical decisions concerning his care. Unfortunately, House and Wilson have taken off on an impromptu road trip without telling anyone, leaving the team to figure out how to treat Treiber while making him believe that House is calling all the shots. Lastly, Chase decides to step out of House's shadow and leave the hospital.
When the team takes on the case of Emily, a six-year-old girl with multiple health issues, they must collaborate with her mother, Elizabeth, who is also a doctor specializing in Emily's condition. Meanwhile, House and Wilson take a little vacation to treat Wilson's cancer in House's apartment.
House and the team take on the case of a young Hmong boy who has violent dreams of being choked and then wakes up but is still unable to breathe. Meanwhile, Park has intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams. Dominika discovers House has kept secret that she received her American citizenship and is free to leave him. So, she does. Wilson has cancer and tells House.
House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker since his current favorite, Emily has decided to get married and leave the business. Desperate for Emily's "companionship," House teams up with his "wife" Dominika to sabotage Emily's budding relationship.
House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson that he has an eleven-year-old son. Chase offers to help Park change her living arrangement and become his roommate.
The team treats an Army veteran charged with treason after leaking classified information. But the patient's life is put at risk when he refuses treatment unless he and his brother receive information about their late father, a war veteran, which raises questions about loyalty to one's family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.
House and the team battle to save a successful, independent blind man who is struck down by a mysterious illness just before he asks for his girlfriend's hand in marriage. Meanwhile, House's mother unexpectedly arrives at Princeton Plainsboro to inform him of her new beau.
A marriage counselor collapses during a speaking engagement. But when put under close evaluation, the team notices behavioral changes that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian green-card "wife," Dominika, make a deal to convince Immigration that they are a happily married couple. This leads to a crash course where both learn something about love and marriage. House chooses Taub as the new team leader.
Chase takes on a patient, Moira, who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. Meanwhile, House and Taub try to remain one step ahead of each other's pranks.
When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
The team treats an underage and homeless female patient. When her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. Meanwhile, Taub has difficulty connecting with his infant daughters, and House threatens to exploit Foreman's relationship with a married woman.
An Alzheimer's patient visits Princeton Plainsboro as part of a hospital-sanctioned drug trial. When he inexplicably suffers violent blood vomiting and an increasingly explosive temper, the team unravels a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, when Wilson tells House about a patient who has never had sex with her husband of 10 years, claiming A-sexuality, House makes a wager that there has to be an underlying cause. Also, House and Foreman butt heads.
A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder.
Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell, and Foreman's lack of romantic relationships piques the interest of Taub and Chase.
The team learns that their 14-year-old patient is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman's firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park tries to get Chase to admit the reason behind his recent obsession with grooming.
A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient convinced he has diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.
A man well-respected in his community suddenly collapses, and in diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, Chase and Taub rejoin the team, and Taub struggles to balance work and fatherhood. House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.
A CEO falls mysteriously ill just days before he signs a contract that would relocate his company's entire labor force to China. House attempts to make an underhanded business transaction with his wealthy patient, but when his condition worsens, the team must work around the clock to save his life. Meanwhile, Park prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman, and Adams' outlook on her patient's business venture reveals her deeper feelings about loyalty.
House and Park treat a patient, Benjamin Byrd, who collapsed suddenly after making a surprisingly large charity donation. When the patient offers to donate an organ to another patient, the doctors must convince Dr. Adams to help them confirm whether Benjamin is in his right mind or not. They are convinced his extreme altruistic behavior is a symptom of a deeper medical disorder. Feelings of guilt hamper thirteen's pursuit of happiness.
A surprising visitor, Foreman, makes House an offer he can't refuse for a conditional early release from prison. This offer allows House to help the Princeton Plainsboro team treat a unique patient to save the life of an organ recipient being treated by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park. After several inconclusive treatments and time running out, House and Dr. Park are left with one last option to examine the patient's medical history that could compromise House's conditional agreement with the hospital. Meanwhile, House makes an effort to reconnect with Wilson despite a cold reception.
House spent the last year in prison at the East New Jersey Correctional Facility after ramming his car into Cuddy's house and attempting to escape responsibility with his trip outside the country. Entirely cut off from his old life, House determines his current problems result from his inability to deal with people. Feeling he will never be able to practice medicine again, he plans instead to return to university to earn a doctorate in physics. This field will all but assure his isolation from other human beings.
When a fellow inmate becomes ill with strange symptoms, House tries to help him while encouraging the young prison clinic doctor, Jessica Adams, to risk her job and trust his diagnosis.
House starts the year in prison, serving out a long term for his various misdeeds in Moving On. However, it turns out that he didn't even try to get a lesser sentence and took a one-year term without complaint. He blows a chance for early parole in order to prove a fellow patient's diagnosis. Although he plans to withdraw from the practice of medicine, it appears the real co-dependent relationship is between House and the hospital. With House looking at serving at least another six months, the new Dean of Medicine, Eric Foreman approaches House with an offer to return to work.
House and Cuddy make their relationship public, but despite the fact that they are both happier than they have been for years, they both see problems. House is sure that Cuddy is merely hopped up on the sex and good feelings that are typical early in the relationship and that she will dump him once she realizes what she's gotten herself into. Cuddy is sure that her supervisory role over House is either going to poison their relationship or ruin House's medical skills, and she's uncomfortable with many aspects of House's past, such as the prostitute he's still seeing for non-sexual purposes. House is also not certain he wants to have a role in Rachel Cuddy's life and starts to balk at the responsibility, although towards the end of the season, House and Rachel seem to share a strange bond over a cartoon about pirates.
After finally realizing that his Vicodin habit is distorting his view of reality, House voluntarily enters Mayfield Psychiatric Hospital to detox. However, detoxing turns out to be the easy part - House can't get his medical license back until he's willing to admit his problems run deeper. Although he resists at first, he finally gives in. At the same time, he falls in love, but then finds his paramour has no further interest in him. When he turns to his doctor instead of Vicodin for help, Dr. Nolan realizes he's ready to return to the practice of medicine.
Wilson slowly starts to recover from Amber's untimely death, but begins to reevaluate his life and to contemplate resigning from his post at the hospital. House's original regret over his role in Amber's death seems to have worn off as instead of being supportive, he merely tries to convince Wilson that he is overreacting to the situation. However, Wilson winds up leaving his post.
After losing his original diagnostic team, House decides that he doesn't need fellows as he feels that he can handle a case all on his own but after taking a long time to solve a case, Cuddy insists that he start looking for possible doctors to join his new team. House grudgingly accepts and gets forty applicants together and has a reality show style contest to see which lucky three applicants will stay on to get the vacant fellowship openings. Meanwhile, Cameron and Chase come back to work at the hospital, while Foreman starts work in a job similar to House's at another hospital. However, Foreman is soon fired for doing exactly what House would do and winds up back at Princeton-Plainsboro. House wants nothing to do with him, but Cuddy insists he can only hire two new fellows and must have Foreman on his team to keep an eye on him.
House recovers from his gunshot wounds, but despite his pain temporarily disappearing and the fact that his leg is working again, he is soon back on Vicodin. He runs into a particularly difficult patient at the clinic, who turns out to be a police officer, who then makes it his business to get House sent to jail for possessing Vicodin illegally. Unfortunately, House has used Wilson's prescription pad to forge his own prescriptions, even though Wilson has been supplying him with Vicodin freely. House nearly goes to jail, but Cuddy then perjures herself in court to have the charges dismissed.
Stacy Warner returns to PPTH, having been officially hired as the hospital's General Counsel. House eventually realizes that he still has feelings for her. In an attempt to prove that she feels the same way about him, he breaks into her therapist's office and reads her file. House learns that she is not sleeping with her husband Mark Warner. He tries to get back with her by killing a rat that has invaded her home, but soon changes his mind after learning that the rat has an illness that brings out the diagnostician in him.
We are introduced to the brilliant, famous but extremely exasperating Gregory House. We learn that despite his considerable intellect and talents as a physician, he does next to no work at the hospital, merely coming in from 9 to 5 to oversee his three teaching fellows. This infuriates his boss, Dean of Medicine Lisa Cuddy. However she keeps him on because when the rest of the doctors are stumped, House swings into action.