Barka is using a lethal hallucinogenic drug to brainwash Nemesis agents and use them as assassins. Tremayne is his latest target, leading Craig, Richard and Sharron to work against time to find an antidote. During their investigations, Richard is captured by Barka and subjected to the same treatment; the target he is given to eliminate is Craig.

This was one of the few episodes that did not feature two stories running side by side. The three agents work on bringing a gunrunner to justice and recovering a consignment of Japanese rifles from the Second World War.

Tracking an unrepentant Nazi who has been released after years in prison in East Germany, the Champions become involved in an attempt to stop him from obtaining an ex-Nazi atom bomb.

After a senior figure in British Intelligence is brainwashed into breaking into his own secure vault (located underneath a tailor's shop) the Champions are sent to test its security and find out what happened.

A spy is captured at a foreign embassy but manages to dispose of the film, hiding what he was doing there. Craig is placed undercover as his cellmate so that he can arrange an escape, take the man with him, and find out who is employing him.

In order to restore stability to a small Middle Eastern principality, the agents kidnap the son of the former Bey (played by Jeremy Brett), who is leading a dissolute life as an exile in Rome. Craig and Sharron fly him into the area but are forced to land due to a sand storm and have to cross the desert (the "journey" of the title) to get him to his destination.

The agents are sent to investigate the disappearance of several eminent scientists—the only link is that all of them have theoretically been seconded to a non-existent "Project Zero". Richard goes undercover as an electronics expert and makes it to the underground base, but is discovered and has to pose as a journalist looking for a story. Craig and Sharron are forced to follow him in.

Richard and Craig investigate Sharron's disappearance while on holiday in Cornwall, and come across rumours of witchcraft. This turns out to be a cover for an entirely different undertaking.

The agents rescue an eminent female scientist who has returned to her home country and been detained against her will by the dictatorship that runs it. This government wants her to do her work there, in order to gain reflected prestige from her medical discoveries.

Barrett, tipped off by a journalist contact, investigates a project in the Welsh countryside that is experimenting with freezing people at the point of death so that they can be revived once medical technology is advanced enough to help them.

The Champions are sent on a mission to recreate the journey of a submarine, which came into port with all of its crew dead from unknown causes.

The trio investigate an operation run by an ex-Nazi doctor who is providing plastic surgery, and hence future anonymity, for international criminals. Craig and Sharron go undercover as an Italian gangster and his moll; however, Richard is forced to move in and masquerade as a vagrant, in order to provide a matching blood group for them (because vagrants provide the raw biological material for the operation).

Craig is captured after a mission in Hong Kong, and held in a cell where he is subject to interrogation by various cruel means. The unnamed interrogator (Colin Blakely) wants information about Craig's last mission. Despite nearing breaking point, Craig escapes the room, only to find he is at Nemesis headquarters; the interrogator is a member of Nemesis internal security, charged with finding out how Craig completed his last mission (his report had been less than clear at certain points, which were where his powers had come into play). Tremayne halts the investigation over the interrogator's protests, but the episode ends with Craig expressing bitterness towards his colleagues for their failure to intervene. All of the three are unhappy with Tremayne as well, owing to his part in the interrogation.

The trio are sent to investigate when several Interpol agents commit motiveless suicide. They discover that an Italian-American gangster forms the only connection between the agents, and set up a sting in which Craig threatens him, so as to discover his methodology.

Whilst on holiday in Haiti, Sharron investigates a plot to brainwash important figures in the worlds of politics, science and business, apparently orchestrated by a local sorcerer, Damballa. Richard and Craig become involved later, only to discover that Sharron has apparently been discovered by the plotters and brainwashed herself.

After burglars break into Nemesis headquarters to access information on Richard, Craig is assigned to monitor him. Richard, however, allows himself to be abducted, leaving a message for his colleague. He finds himself imprisoned in a luxurious room (the "gilded cage" of the title), where his captor (John Carson) threatens him that, unless Richard can decipher a code, a young woman, Samantha (Jennie Linden), will be killed.

After a nuclear submarine is stolen by ex-Nazis who are determined to use it to continue the war, the Champions are tasked with hunting it down.

The Champions are assigned to escort an Eastern European head of state, Dubrovnik, on his visit to Britain. During a dive in a Scottish loch, their submarine is sabotaged and Dubrovnik is injured. Richard and Sharron are forced to face down a mutiny within the crew, who want to surface and save their lives; the submarine cannot be allowed to surface if Dubrovnik is to survive the surgery, which Sharron has performed.

An unknown organisation is assassinating international leaders. Richard, posing as a convicted traitor, is sent to infiltrate the organisation and try and bring it down from within.

The Champions are sent to investigate a tropical island where visitors have a history of disappearing. Coming on shore in two parties, they discover and thwart an international conspiracy to threaten world peace.

The Champions investigate a mysterious 'ghost plane' which is both faster than anything else in the air and of unknown origin.

This was one of the more comedic episodes.The trio are detailed to guard the former dictator of a small South American country, La Revada, who is living in exile in the South of France. This is because some of his political opponents are planning to assassinate him, which would destabilise the political situation in the region. El Caudillo (as the former dictator insists on being called) turns out to be a vainglorious, not-very-intelligent womaniser who likes to prove that he is superior to everyone around him.

Using Sharron as a decoy, the agents investigate a drug-running racket in London.

The trio are sent to investigate the possibility that caches of guns have been left in Austria by the SS, and end up discovering a secret Nazi hideout in the local iron mines, complete with surviving Nazis who think the Second World War is still going on.

Craig and Richard are sent to Antarctica to investigate an unexplained nuclear explosion, and discover that an unnamed South American country is using the territory to develop its own nuclear weapon.

Sharron, Craig and Tremayne are in Australia observing a nuclear test. Meanwhile, Richard is trapped at ground zero with amnesia, trying to stop the men who are attempting to sabotage the test.

Sharron is sent undercover to a training establishment in which a scientist is using new techniques to produce agents who have the same level of abilities as the Champions. Nemesis is interested in the organisation because one of its graduates has tried to break into a military establishment and steal secrets.

The agents are sent to the Caribbean to investigate a newspaper advert asking for "a parrot that speaks Greek", which Tremayne has worked out is a signal for participants in an undercover operation.

The agents investigate a plot to steal the gold reserves of a bank in the City of London

The three Nemesis agents recover from a plane crash in the Tibetan mountains to find their injuries healed. In the course of the episode, they learn they have had new abilities bestowed on them by their rescuers, people from an ancient civilisation, and have to evade capture from the Chinese military.