Tara is a single mother of two who feels like a prisoner in her own body. Riddled with joint pain, she is determined to lose the weight and see her kids grow up.

38-year-old James has lost both his father and sister to obesity-related issues. Now, at a staggering 650lbs, he is facing the exact same fate.

Paula has had a tough life, and at over 272kgs, has built a physical wall around herself to push people away. But can she shed the pounds and turn her life around?

Christina hasn't left her house in two years due to her size. She's eaten herself into a state that will soon kill her, but can she make a dramatic change?

Chuck's weight limits everything he does, preventing him from doing even basic things for himself. Can weight loss surgery help him to turn his life around?

Penny's weight forced her to spend the last four years living in her bed. This is her last chance to have a family and life worth living.

Olivia's weight controls her life and prevents her from being able to do many things. She desperately wants her life back - but is she ready for a drastic change?

Zsalynn weighs close to 300 kilograms and has to rely on other people to take care of her nine-year-old daughter. Is this enough motivation for her to make a drastic change?