Marla is so heavy she cannot stand up. Bedridden, she must face the facts about her health and the toll it takes on her supportive family, if she is to save her health.

To cope with the emotional turmoil of his childhood, 23-year-old Chay has eaten his way to 600-lbs - and it's threatening to kill him before turning 30.

An overweight woman struggles with flesh-eating bacteria and butterfly shaped fat deposits; unexpected news threatens her weight loss journey.

Laura has used food to cope with her emotions for too long. Confined to a wheelchair, she depends upon her husband and mother to survive. Can she turn her life around?

Joe is only 30, and trapped in an 800-lb body. He lost his job and is mostly housebound. Can Joe find the strength to face his past and save his life?

At 42 years old, Angel is staring death in the face. She is struggling to make a positive change and be an active part of her partner and son's lives.

At just 24, Bettie Jo is eating her way towards 700lbs. Housebound, she is reliant on her husband for even basic needs. Can she shed the pounds?

Pauline is 51-years-old and nearing 700 pounds; her addiction to food has taken over the life of her son and primary caretaker.

At over 600lbs, Susan is committed to drastic weight loss. But when a medical disorder affects her mobility, her plight becomes a matter of life and death.

At age 23, and over 600 lbs, Amber relies on her family for even simple needs. Her fear of dying young sends her 2,000 miles for weight loss surgery.