At 272kg, Lupe has spent the last ten years in bed. A doctor in Texas is her only hope for change, but has she waited too long to begin her weight-loss journey?

Sean has a massive growth protruding from his side and skin so stretched it's tearing apart, forcing his mother to change both of their lifestyles before he can be approved for surgery.

Milla is bedridden and dependent on her husband and five kids, who can't resist her unending requests for junk food.

Randy's food addiction dissolved his marriage and keeps him from seeing his daughter, so he endures a rigorous pre-surgery diet surrounded by fast-food temptations to regain control of his life.

At over 700lbs, Teretha's life is confined to a bed. Her family fears losing her and hopes a gastric bypass will provide the solution she needs to save her life.

Weighing over 700 pounds at 26-years-old, the clock is ticking on Ashley's life. Ashamed of her body, surgery offers hope, but not without setbacks.

At 650 pounds and Desperate for change, Gideon uproots his family to restart his life with weight-loss surgery and hopes for a future of happily-ever-after.

Dottie loves being a mom but, at over 600lbs, she's on the verge of leaving her 2 young children motherless. Can she take drastic action and turn her life around?

600-pound June copes with the tragic death of her son by eating. After gastric bypass surgery, she must confront the emotional issues driving her food compulsion. If she can stay on track, she can become the mother she desperately wants to be.

At 700 pounds, Chad's weight is dangerously out of control. After gastric bypass surgery, he quickly sheds pounds but faces a medical crisis when he does not follow the doctor's orders. In dire straights, Chad puts his weight loss journey on the line.

Brittani married a man who loves large women, but at 600-lbs, she can barely contribute to their marriage, and gets surgery to try to have a normal relationship.

Explores 10 years of documentation of the super-obese to highlight key breakthrough moments within their turbulent but ultimately triumphant weight-loss journeys.

Nikki finds her career as a costume designer threatened by immobility, so she undergoes gastric bypass and confronts the emotional causes for her eating.