Sean must overcome recent tragedies in his life before he loses all the progress he's made over the last two years; Dottie struggles to stay on track while maintaining her family life and dealing with new pains in her body.

Brittani has lost over 400 lbs. in two years. As part of her next chapter, will she and Bill start to plan to expand their family? Lupe has struggled since surgery. Having left her husband, will she finally start to make permanent changes she needs?

Ashley hits an emotional wall and is desperate for skin surgery, but she is not losing any weight. After being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.

Losing over 200 pounds, Doug is now an active part of his family's lives and inspires a healthier lifestyle for them all. However, Doug's eating disorder and trouble finding his own identity threaten to derail his progress.

Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses; Cynthia continues to lose weight but seems satisfied to do so at her own pace.

Kirsten must finally become independent to get the full gastric bypass surgery she feels she needs; Michael struggles to lose and still battles anger issues; and Michael's wife, Roni, wants her own surgery.

Ashley lost over 200 lbs. in Houston, but she faces the fact of regaining independence and struggling to lose weight back in California with her family of enablers; and Diana has embraced her new life and shed 300 lbs., but her knee damage might threaten her progress.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lost more than 400 lbs. and are working toward skin surgeries when a major life event disrupts their world and threatens the security they thought they had.

With the Perrios struggling with different stages of their weight loss journey, the revelation of a past tragedy explains their resistance to recovery. They must now come together to overcome their fears & forge a path towards a healthy future.

After a lifelong struggle with obesity, the three Perrio siblings travel to Houston in a last-chance journey to lose weight. Will they be able to break decades of unhealthy habits without fracturing as a family?

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain of 150 pounds.

A 400-lb. woman learns that she's pregnant, but wonders if she'll be able to deliver the baby without complications; a woman who lost 400 pounds is in a relationship, but it could be in jeopardy when her weight-loss journey stalls.

Jennifer and her daughter Marissa are stuck in a codependent relationship that has put both of their lives in jeopardy, with a combined weight of over 900 pounds.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her, but there's no guarantee that weight-loss surgery be able to fix her fertility issues as well as her marriage.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah weighs over 600-lbs and is fighting for her life at only 24 years old.

A former plus-size model and ‘big is beautiful' advocate, Renee now realises her mortal mistakes as her weight swells to 600-lbs and her health crumbles.

Brothers Benji and David were raised on fast food. At 700-lbs, David is unable to work and Benji, now 475-lbs, fears that he is heading down the same road.

A tumultuous relationship with her husband caused Tamy Lyn's weight to reach more than 500lbs. Isolated from the outside world, she needs to restart her life.

At nearly 900lbs Robert is bed-ridden and living in a nursing home, with lymphedema masses on each hip. Can he make the radical life changes needed to save his life?

Lisa's struggle with weight worsened after witnessing her brother's murder. Now bedridden, she must lose the weight or never see her grandchildren grow up.

James LB Bonner spent his early life trying to prove himself to his adoptive family, but after losing a leg and battling obesity, LB must take a new path to save his health and his family relationships.

Unable to stand for more than a short period of time, Karina's weight places a burden on her parents and drives a wedge between her and her sister.

Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk; utterly isolated, Liz has no friends, battles depression and lives with a mother too ill to take care of her.

Alicia, all smiles and laughter on the outside, secretly fears that her food addiction will kill her before she can marry her long-time love or watch her nieces grow up.

Because of her morbid obesity, Janine relies on a motorized scooter to get around, and must push through emotional and physical pain to live her dream life full of fun; with insider facts and bonus scenes.

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while making a desperate, second attempt to save their lives.

Steven Assanti's dysfunction escalates, pushing his relationship with Dr. Nowzaradan to the brink, and a risky decision is made to save Steven's life, while brother Justin takes the leap to go to Houston to finally accept help.

Steven Assanti's dysfunction escalates, pushing his relationship with Dr. Nowzaradan to the brink, and a risky decision is made to save Steven's life, while brother Justin takes the leap to go to Houston to finally accept help.