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While the team searches for connections between a group of people abducted from a coffee shop, Jack is up for review and Samantha goes into labor.
Connor Baynes, a man who recently saved a child from being hit from a bus, goes missing.
After Lacey Moran, the latest lottery winner, goes missing, the team looks at her friends, family, job, and the people she knew.
The team searches for Jay McCann, a coma patient who had woken up after three years only to disappear.
While Jack fights for his life, the team takes on a case involving the disappearance of a teenage heart transplant recipient who was looking for information about the boy whose heart she received.
Jack goes missing after taking a case into his own hands which soon becomes intertwined with a human trafficking prostitution case that Vivian is working on.
Laura Richards, a veterans-hospital worker who made the prosthetics for the injured soldiers, disappears.
Malone and his team start off the new year investigating how private investigator Scott Lucas might have gone missing.
Glen Beckett, a child prodigy turned store Santa, vanishes and the team wonders if he had criminal connections.
While the team investigates the disappearance of an ex-con who served time for embezzlement, Agent Johnson gets a possible break in her case involving the kidnapping of a young woman.
Detectives investigate the disappearance of an ultimate fighter, and Samantha tracks down her baby's father.
A college student disappears after his racist statements are posted on an Internet video site.
When a serial killer eludes capture in Nevada and escapes with his son to New York, Jack and the team pick up the trail with the help of CSI Las Vegas team leader Gil Grissom (William Petersen).
This episode concludes a crossover with CSI: Crime Scene Investigation that begins on "Who and What".
A woman disappears after an office shooting, but the case appears to be tied to a custody battle.
A young woman disappears after her boyfriend is killed in a police shooting. Sam learns she is pregnant after a one-night stand.
A television reporter's disappearance is tied to her son's torture and death in a Guatemala prison.
A crime scene cleaner and his daughter are missing.
A Sudanese boy adopted by a high-profile New York couple disappears.
The viewer is introduced to the missing persons unit, headed up by the driven but morally compromised Jack Malone, whose professional successes are marred by his complicated personal life—he is in the midst of a messy breakup from his wife, precipitated by his own infidelity with his protégé, Samantha "Sam" Spade. At the outset of the series, Jack struggles to balance his crumbling marriage with the arrival of Martin Fitzgerald, a rookie agent whose placement Jack sees as a sinecure due to Fitzgerald's father being a powerful figure in the FBI. The team ultimately find themselves forced to come together and personally reckon with the legacy of 9/11 when a businesswoman whose company headquarters were destroyed in the Twin Tower attacks is kidnapped by a man whose wife was killed in the World Trade Center.