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After a late night dive, Derek Wilson disappears and the team tries to determine why. Danny and Elena prepare to make the next step in their relationship.
Jack's daughter Hannah's boyfriend disappears soon after he moves from Chicago to New York to be with her.
A young woman's kidnapping is accidentally recorded on a pirated DVD bought in Chinatown.
A journalist investigating a politician disappears.
Keith Anderson, a billionaire's son, disappears after crash landing a small plane in the woods.
The suspect list keeps growing as the team investigates the disappearance of Lana Peters, a Russian matchmaker.
Justin Morgan, a psychologist, goes missing right after stopping a woman from jumping off of a building.
Zack Porter, a trial consultant goes missing and the team narrows down the list of suspects as they investigate his disappearance.
Kara Westfield and her son Hayden go missing from the local community centre after a fire alarm clears the building.
What appears to be the disappearance of a college student becomes more complicated when the team discovers that the victim is an impostor with multiple identities.
The team searches for Julie Fisher and Cate Conelly. The two neighbours were abducted from their homes.
Agent Delgado's former police partner goes missing after an undercover deal goes bad.
The team searches for Ken Gilroy, a bar owner, who goes missing shortly after his statue of St. Theresa cries. Brian's visit with Sam takes a new turn.
A 13-year-old girl torn apart by her feuding parents over custody and visitation rights disappears.
The disappearance of a mean spirited, self-centered weatherman who had recently tried to change his ways leads the FBI to a group of Civil War reenactors.
Doctor Erica Loza goes missing shortly after treating a patient and the team suspects a secret from her past is connected to her disappearance.
The team's latest case sends Jack and Sam to Los Angeles in search for Robb Simms, a man who went missing after his employee's funeral.
The squad discovers a shocking truth during an investigation of Chris Howe, a missing paraplegic recently injured in a car accident. The team also continues to adjust to normal with Jack back as the head of the department.
Erin MacNeil, a bank manager, disappears and the team uncovers a dark secret during their investigations. Jack returns to his job as head of the department.
Martin is left on his own to solve the disappearance of Arianna Murphy, a victim's advocate from the scene of a double homicide, when Agent Medina diverts the rest of the team to investigate the abduction of a little girl from a mall.
Will Duncan, the teenage son of a Secret Service agent, disappears and a long-festering secret that set a deadly chain of events in motion is discovered.
Alan Reynolds, a white-collar criminal, goes missing on his way to testify against a former associate.
Sara Kent, a rising executive, is abducted from a taxi after attending a rooftop party. The team also continues to learn to adjust to their new boss.
A man whose daughter disappeared years earlier disappears himself while searching for another lost child. Meanwhile, Jack is relegated to desk duty as the new boss comes in.
The viewer is introduced to the missing persons unit, headed up by the driven but morally compromised Jack Malone, whose professional successes are marred by his complicated personal life—he is in the midst of a messy breakup from his wife, precipitated by his own infidelity with his protégé, Samantha "Sam" Spade. At the outset of the series, Jack struggles to balance his crumbling marriage with the arrival of Martin Fitzgerald, a rookie agent whose placement Jack sees as a sinecure due to Fitzgerald's father being a powerful figure in the FBI. The team ultimately find themselves forced to come together and personally reckon with the legacy of 9/11 when a businesswoman whose company headquarters were destroyed in the Twin Tower attacks is kidnapped by a man whose wife was killed in the World Trade Center.