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The team takes on the case of a teenage girl who disappears after joining a cult.
A high school student disappears on prom night.
A divorce court judge goes missing, and the team finds a link to a woman from his past.
The team searches for a stuntman who went missing shortly after completing a dangerous, fiery stunt.
Tess Pratt lets go of her son Andrew's hand for just a moment at the marketplace, but that's all it takes for the six-year-old boy to disappear.
Sam's sister goes missing, so Sam decides to look for her without consulting with the rest of the team. Throughout her investigation, Sam's past unfolds.
The team searches for Rebecca Howard, a fifteen-year-old girl who lived with her grandfather and was last seen at an Internet café.
Patricia Mills, a newly elected senator goes missing and Jack immediately turns his attention towards her husband.
Elena is frantic when her daughter Sofie goes missing, and the team has a full schedule as they must also search for a missing tourist.
The team searches for missing water plant supervisor, Jason Turner, and learn that he had become the target of a lot of anger after recent layoffs at the plant.
Abby Horton, a young artist who creates her art by taking pictures of unsuspecting strangers disappears.
A competitive eating champion, Barry Rosen, vanishes after winning a chili eating contest.
Neil Rawlings, an air traffic controller disappears after nearly letting two planes collide on his watch.
Ted Soros disappears after playing in a high school basketball game.
Vivian thinks about her recent surgical problems while searching for Audrey West, a woman with a terminal condition.
The team investigates the disappearance of social worker Eric Hayes who had given thirty days notice to his job not long before.
Jack and the team investigate the disappearance of Alex Stark after his girlfriend reports him missing.
Martin brings the team in on a hunt for Katie Duncan, a young woman that went missing after a priest attempted to exorcise a demon from her.
The team investigates when Aaron Gibbs goes missing and learn that Aaron's disappearance was connected to events that took place during Hurricane Katrina when Aaron was fighting to save his sons.
The team investigates when Sadik Marku's son and girlfriend go missing.
The team investigates when Malia Norton, a teenager at a detention center, disappears after being threatened by one of the other residents.
The team searches for Jessica Lawson, a 911 operator who disappeared after a man who knows her called her.
Cindy "Candy" Peterson, a mother who had become a stripper to support her family, goes missing one night after work and Jack sends Elena undercover at the strip club to learn what she can.
Bryan Parker is questioned by the FBI after being found alone on the road by a police officer, his hand bandaged. He tells them about a young boy his father had abducted.
The viewer is introduced to the missing persons unit, headed up by the driven but morally compromised Jack Malone, whose professional successes are marred by his complicated personal life—he is in the midst of a messy breakup from his wife, precipitated by his own infidelity with his protégé, Samantha "Sam" Spade. At the outset of the series, Jack struggles to balance his crumbling marriage with the arrival of Martin Fitzgerald, a rookie agent whose placement Jack sees as a sinecure due to Fitzgerald's father being a powerful figure in the FBI. The team ultimately find themselves forced to come together and personally reckon with the legacy of 9/11 when a businesswoman whose company headquarters were destroyed in the Twin Tower attacks is kidnapped by a man whose wife was killed in the World Trade Center.