After attorney Jennifer Nichols disappears, the team investigates the last few days in her life and soon find that she had grown disillusioned with her most recent relationship with Allen Davis.

Jack finds himself in the hotseat when Emily Grant, a young white woman and Darnell Williams, a young black man, go missing on the same night and Jack is ordered to put more of the team's resources into finding the young woman.

The team searches for Ted Jordano and his teenage children after the three turn up missing and their house is a veritable bloodbath.

The team searches for a teenage figure skater who disappears after practice one day and discover that many people in her life had reason to worry. The team's investigation leads to the rink's operator, a convicted rapist who was the last to see the girl.

After Breck Mulligan goes missing from the women's shelter he had been working at, the team is called in to investigate. Breck was originally assigned to work at the shelter as part of a his probation for drug related offences, but the plight of the women and children seeking help had gotten to him and he had continued to work for the shelter, even going so far as to sleep with rich older women to get donations to help the shelter. The team is surprised to learn how little faith Breck's family and friends had in him, discovering that his friends had staged in 'intervention' the night he went missing, trying to convince him to walk away from his new life.

Megan Sullivan is H.I.V. positive, pregnant and missing. Initially the team suspects that her husband, who seemed to be less than thrilled about the baby, is involved, but soon learn that Megan had received a call from a prison, and their search tracks them to a former lover, who gave her H.I.V., her husband's former mistress, who had seen her taking part in a tense conversation not long before she vanished, and her own H.I.V. specialist, who had recently given her bad news. Martin thanks Danny for his help, and tells him that he is continuing to seek counseling for his addiction.

The team searches for 18-year-old Brandon Parker only to learn that 15-year-old Matt Jameson had stolen his former teammate's identity in order to get a job to support his three younger siblings after his mother had taken off. They manage to connect Matt to an old friend from a former foster home, Casey Miller, and soon realise that Matt has gotten in over his head while trying to keep his younger sisters and brother together. Sam starts to get suspicious of Martin's behavior and confronts him on his drug addiction. She goes to Danny looking for help, but Danny is reluctant to get involved in Martin's problems.

The team tries to track down a reclusive columnist who hadn't left her apartment in months and was communicating with numerous prisoners.

The team investigates after five-year-old Ethan Heller is carjacked from the family car, and Danny starts to figure out what's going on with Martin.

When Leah Robinson goes missing after a confrontation with a young man at an art gallery, the team mvoes in to investigate and soon become suspicious of Leah, suspecting her of murdering young women that she believed to be involved with her husband, Ken. Ann isn't quite ready to take her romance with Jack public, and their relationship gets rocky when their different methods of handling the case tip off the suspect.

The agents investigate the disappearance of Andy Reynolds who vanished after appearing in a police line-up in a rape case.

The agents investigate the disappearance of Claire Hunter, a prep school teacher who was last seen at her gym the previous evening. 

After therapist Gina Hill disappears, the team investigates and initially suspects that one of her patients may be involved.

The FBI investigates the disappearance of Cole Warren, an FDNY paramedic who was last seen at the hospital after delivering a wounded gang banger.

While Jack tries to determine what to do about his increasingly frail and delusional father, Sam investigates an unidentified amnesiac woman in the mental ward of the hospital.

Jack's friend Max Cassidy vanishes after leaving a message on his wife Anne's voice-mail. 

This case, a missing 15-year-old school boy, focuses on the emotional anguish of the parents as the team does its best to find him.

When the team investigates the disappearance of a man, they find pictures of child pornography in his home office and on his computer.

Jack and Danny head to Mexico to find wealthy American vacationer James Costin who was abducted, at the request of James' mother-in-law. While Vivian, Sam, Martin and Elena work the case back in New York.

The team searches for 25-year-old Korean-American Wendy Kim, who vanishes after a fight with her new boyfriend during her night shift at her parents' deli.

The backpack and ID of missing college coed Skye Petersen are suddenly dropped off at a thrift store seven years after Jack--and ultimately the legal system--determined she was murdered by her married professor with whom she'd just ended an affair.

The team's newest member, FBI rookie Elena Delgado, formerly of the NYPD, encounters a learning curve as she attempts to help search for missing 20-year-old Dina Kingston.

The team searches for missing 15-year-old Ryan Wallace who was obsessed with the safety of his school after losing a parent and watching the towers on 9/11 fall. Martin and Vivian both return from medical leave.

Martin and Danny attempt to dodge a hail of bullets as a mercenary and his cronies try to kill their true target, an FBI detainee whom the agents are transporting.