When a young Boxer falls from a 2nd story window, the team races to the rescue. Dr. Jeff discovers a life-threatening problem in a Great Dane. And, after a beloved cat is attacked by a mystery animal at night, Dr. Don battles to save his leg.

Dr. Jeff and his team head to Romania to help with a street dog problem that's out of control. Jeff attempts complex surgery to help a dog hear again. And, the team ventures into the mountains to help a European Bison that's suffered a brutal wound.

Dr. Jeff takes on a high-risk surgery to save the life of an adored puppy. A three-day-old orphaned kitten needs Dr. Baier's help to stay alive. And, a pup is given a fifty-fifty chance of survival after it's rushed into the clinic with a deadly virus.

An emergency surgery yields a surprising discovery; treating a goat that has been kicked by a horse; a couple travel a long distance to fix their dog's shattered leg; treating an injured ostrich.

With a puppy's leg on the line, Dr. Jeff attempts a new surgical procedure; a ferret bites off more than it can chew; a disturbing discovery while treating a cat; treating rescued bears.

Dr. Jeff and his team head to Mexico to help pets and their owners in desperate need. Dr. Jeff helps a teenage boy and his sister worried about their sick dog. And the team head to a remote Mayan village to treat dogs that have never seen a vet before.

A cat with a shattered paw needs Dr. Jeff's help to walk again. Dr. Baier treats a rescued opossum in need of a new home. And the team heads to an Indian reservation in South Dakota, where a badly injured dog steals Jeff's heart.

An abandoned puppy is found with a broken leg; the team cares for a seriously ill Boston Terrier; doctors head out to treat rescued pigs.

There's no such thing as "a regular day" at Denver's Planned Pethood Plus veterinary clinic. For 80,000-plus clients and their pets, the clinic and its maverick vet Dr. Jeff Young represent one last hope, and possibly the difference, between life and death.

When a beloved black lab swallows toxic metal, Dr. Jeff races to save his life. A lost cat is found after a year and a half absence, but has a mysterious injury. And, a tiny dog has a big, life-threatening problem.