A series of misadventures plagues Trampas as he travels to Mexico on Shiloh business.

The Virginian arrives in Monolith, Arizona to buy cattle from the Landers family but finds himself in the middle of a feud between them and the city marshal Merle Frome and his brother Ben. The Fromes seem overbearing but maybe with a reason.

To help an old cowboy keep his grandson's respect, Trampas lets the man work at Shiloh Ranch but soon regrets his decision.

The Virginian goes to Honesty, Wyoming to collect $8000 owed the Judge on a crooked cattle deal. The town is owned and run by the corrupt man who owes the money. The fight over the money spills into a murder charge against the Virginian.

Trampas is deputized to escort a murderer back to a town where he knew the sheriff. There is a question of the man's innocence plus Trampas learns the sheriff died in a horse accident two days later. He decides to investigate the questionable stories.

A cowhand courts a logging boss's daughter, threatening any compromise in a dispute between timbermen and ranchers.

A marshal who believes he is infallible arrests Randy for a murder that occurred during a bank robbery.

Ryker dodges two vengeful brothers and tries to figure out why a beautiful woman is marrying a shy storekeeper.

The Virginian hires a man kicked off a cattle drive by the trail boss even though he is half owner of the herd. The herd passing Shiloh is suspected of having Spanish Fever. The man returns to the herd but his immaturity creates problems.

While in Albuquerque, Trampas pretends to be a hired gunfighter to romance a beautiful woman who is practicing a puzzling deception of her own.

The Virginian rescues a woman from a stage wreck, but amnesia prevents her from realizing her life is in danger from two outlaws after hidden loot.

Searching for the killer of six gold miners, Ryker meets a young woman whose long missing father was one of the victims.

A ride through the mountains turns dangerous for Betsy when she discovers a legendary herd of horses and a mysterious father and son who fear she will reveal their existence.

Judge Garth delves into psychology to comprehend a gentle, poetry reading cowboy accused of two brutal murders.

A rancher refuses to allow cattle belonging to Garth to escape a landslide by crossing his land; the Virginian falls in love with a Chinese laborer.

Garth opposes a congressman's plan to settle immigrants on barren land.

Ryker firmly believes his stepfather has reformed and ignores evidence indicating the older man is gathering people for a new outlaw gang.

A French portrait painter returns from Chicago to Medicine Bow with Betsy and a new widow to paint her. The Judge suspects he is not being truthful but he seems to be the right medicine for the grieving widow as the Judge investigates.

A feud between ranchers and a railroad tycoon result in murder charges against a rancher when the tycoon's son is killed. Ryker and the Judge try to prove his innocence but must rely on a woman who disappears deserted by the murdered man.

A lawyer wins the acceptance of Medicine Bow's people by helping the Virginian in a legal matter, but loses favor when she uses her skills to free three outlaws from jail.

A local miner's son returns to Medicine Bow from college with the technical knowledge and financial backers to reopen his father's silver mine. Due to financial constraints, corners are cut putting people and cattle in danger.

Steve is asked by a US Marshal to renew an old relationship with a woman who is now believed to be part of the Wade gang. The reluctant Steve goes along with the idea but finds it a hard task made harder when old feelings resurface.

A boy in an orphanage near Shiloh latches onto Trampas as his father while Trampas is attracted to the woman running the orphanage. Trampas agrees to help the boy but when his father arrives on Shiloh with men chasing him, problems arise.

A self important businessman is pushed off a train and found by The Virginian and Steve on a cattle drive across a desert. He is forced to work his way on the drive and learns some lessons about himself and his impact on other's lives.

A newspaper reporter's exaggerated stories put bounty hunters on the trail of the Virginian.

Everyone raves about Felicity, the new Medicine Bow school teacher. The Shiloh hands, including Steve Hill, are all smitten but her heart is won by the Virginian who proposes to her. However, Felicity's family protects some secrets which eventually brings an end to the Virginian's marriage plans.

Trampas suspects a writer doing a story on possible senatorial candidate Garth may be working with a lawyer to threaten the jurist with blackmail.

A wild stallion escapes its owner, killing a handler in the process. The animal injures itself and is found by Randy who takes it to the nearby ranch of alcoholic horse trainer Charlie Orwell, who nurses it back to health. Most believe the horse bad and wish to have it destroyed but Randy gets Charlie to help him save the animal and with the help of Jodie Wingate, they save Charlie too.

A family moves nearby with a pretty daughter drawing the attention of Trampas. However, when he pushes her to dance, he learns she has a club foot. This is compounded by the pressure on her brother to support her in lieu of his own life.

Ryker is offered the job of stopping a small rancher from paying a mortgage. He is too honest to do it but is framed for killing the rancher. He is a good lawman and the sheriff wants him as a deputy but Ryker wants to save his name first.