While hunting for a cougar, Trampas offers food and shelter to a half starved boy who hesitates over accepting or remaining in the hills to rendezvous with an outlaw gang.

Sheriff Dan Porter leaves his job as sheriff of Mason City to follow his wife Emily to Medicine Bow as she can't handle the pressure of his job. He signs on at Shiloh to learn ranching so he can start a ranch and new life with his wife.

A rancher halts his feud with Shiloh over a strip of land between Shiloh and the Bowden ranch when he mistakes a drifter for a gunslinger.

A buggy accident leaves Stacy's arm paralyzed, and he sinks into self-pity after an operation apparently fails and his girlfriend abandons him

Tired of his dad's treatment, Kiley Cheever heads to Medicine Bow to find his childhood friend Trampas and a job. Kiley's tendency to make up stories and prove his manhood gets him into trouble with everyone but a female visitor to Shiloh.

Trampas, Stacey and Elizabeth are caught in a sandstorm while returning to Shiloh with a bull. They take refuge in an abandoned homestead where several guests arrive after them with one thing in common – connections to a robbed bank.

Elizabeth and Holly care for a wounded outlaw, who faces a dilemma when his recovery means either being turned over to the authorities or facing a pursuing bounty hunter

Three convicts come to work at the Shiloh Ranch as part of an experimental parole program.

Trampas is sent to Carrsburg to check stock so he asks for a couple of day to visit a female friend. On the way he is asked by a dying prospector to find his niece who can only be found by birthmark on her leg. The result is trouble with his female friend.

Clay tries to prevent a range war between the ranchers and the homesteaders who are blocking their path to market. A hotheaded rancher secretly hires a gunfighter who happens to be an old friend of Trampas, who falls for Abby Keefer, a homesteader's daughter.

First Trampas and then Holly and Elizabeth encounter a military prison wagon crossing Shiloh land carrying a prisoner who appears to have scarlet fever. When he escapes, they are worried who may be infected with the disease.

A Canadian cattle buyer who owns his own city pays the Virginian $100,000, then has his henchmen rob the local bank, rendering the Virginian's bank draft worthless.

The injury of an old girlfriend's daughter convinces the Virginian to stop a rich rancher's spoiled son who has been terrorizing a town.

After a fortuneteller predicts death, Trampas and two other Shiloh hands face a gunslinger as they pass through a doomed town after delivering cattle to an Army base.

The Virginian faces mixed reactions from the father, sister and vengeful brother of a young outlaw he was forced to kill in self defense.

Trampas' investigation of a doctor's possible involvement in a murder makes the Shiloh ranch hand the victim of insults, a drugging and a beating.

Frank Hollis is released from prison and returns home to find his dad was injured saving Trampas and is forced to take a stable job at Shiloh. Frank has a chip on his shoulder due to people's attitude about him and that Grainger has not done more for his father. 

Trampas is sentenced to hang for a murder he didn't commit. The Virginian and Stacey try to find new evidence while Clay Grainger and the attorney try for a new trial. Meanwhile, a desperate Trampas escapes prison with his cell mate.

A herd from Texas is brought in by Kyle Jackson and his brothers. However, things turn tragic when Trampas discovers the herd is sick and a brother accidentally kills the wife of an ex-lawman.

An alcoholic lawyer is prodded into fighting prejudice and the bottle to defend a Chinese immigrant who has been denied his legal rights.

Note: This is the last episode with Charles Bickford as John Grainger due to his unexpected death from pneumonia and infection.

Bank teller George Foster has told his ex-lawman dad he is a sheriff to make him proud. When his father is to stop by for a two hour visit, Ryker and The Virginian decide to make him Sheriff but they didn't expect the visit to be extended.

An injured Canadian Mountie refuses to give up his pursuit of a wanted man, although out of his jurisdiction into Wyoming.

Ryker sidesteps the law to help a robbery suspect plagued by a blackmailing Shiloh hand.

Two Wichita saloonkeepers inherit property and arrive in Medicine Bow intending to be proper members of society.

Suspense builds as Trampas, a hard drinking gunslinger and a sheriff's wife search for the person who has sent them death notes.

On a cattle buying trip, the Virginian becomes involved in another transaction: freeing Elizabeth from an outlaw with an old score to settle.