A young Kansas City woman comes to Medicine Bow so see if an outlaw Ryker captured might be her brother as they were both orphaned at an early age. 

John Grainger asks an old friend from Maryland to come to Shiloh to take the rough edges off his grandkids. She does as he asks quite well but is less than popular with the kids and The Virginian. Unknown to them, she has a secret plan.

Trampas falls for a beautiful but elusive girl whose problems go beyond shyness.

Trampas settles a score for an old friend whose son has been unjustly killed.

The Virginian steps in to help a farmer called cowardly by his family when he refuses to raise arms against a rancher trying to drive him from his land.

Stacey is shanghaied in Medicine Bow to take the place of a cavalry recruit. An inept officer allows two sergeants to keep up the facade that Stacey is a recruit while putting him through inhumane conditions to keep him quiet.

A woman physician comes to Medicine Bow and must battle the prejudices of her colleague and townspeople.

Romance blossoms between Trampas and a wealthy, spoiled Chicago woman visiting the West with her father, who is looking to buy a ranch near Medicine Bow.

Murder is one of the unfortunate events that results from Stacey's determined courtship of a young woman whose father objects to the match.

While returning from Mexico on business for Shiloh, The Virginian is shot by a rustler while crossing a large Texas ranch. He recuperates with a Texas family but discovers he has become a pawn in a kidnapping plot and may have to face a deadly gauntlet

After holding up the bank, Dell Stetler and his partner hold the Graingers hostage at Shiloh to help their wounded comrade. John is forced to bring the doctor to Shiloh to tend to the man as he and Stacey plot a way to free themselves.

The Virginian looks for Stacey in a town where they are to finish up a cattle deal. His search results in finding Stacey in jail found guilty of murder. He is to hang the next morning forcing The Virginian to find the real killer fast.

A peddler's watch points to a wealthy girl, an Indian reservation and perhaps to the killer of Stacey's father.

Sue Ann leads a dull life as the daughter of a homesteader taking care of her father, two young brothers, and their hired hand Joe who would like to marry her. She leaves home to see San Francisco, but where will she get the money?

After Stacey Grainger kills a would be robber, the dead man's brother seeks revenge.

A spoiled woman insists her fiancée, a Shiloh ranch hand, open a store and become a businessman after they are married.

A bank robber quits after an unprofitable heist and returns home, only to rival the Virginian for his son's affections.

Upon returning from Texas, The Virginian finds himself in the middle of an express line holdup. On the stagecoach, he meets a beautiful woman who ultimately confides in him that she is a courier carrying a package – possibly illegal.

Elizabeth bids successfully for an untamed white colt, then sets out to train the animal to race at an upcoming county fair.

The Virginian sets out alone to a ghost town to find the two men responsible for the death of a young cowboy.

A sixteen year old New York City girl on her way West reads a dime novel enroute, arriving with a romantic notion about cowboys which she directs at the Virginian.

Trampas, aided by a local citizen, pursues a man he believes committed a murder for which an innocent man has been jailed. They encounter others who hinder their progress and an unhappy couple.

A man wanted for murder and robbery escapes jail and ends up in Medicine Bow where he befriends Stacey in a fight. He goes to work at Shiloh as a ranch hand and Elizabeth takes an interest in him. However, Stacey is less certain about him.

After a stagecoach holdup and accident, Trampas stumbles into a farm with a concussion and amnesia. The farmer and his two kids tend to Trampas, but the white handled gun he is carrying puts him into danger from the law and the outlaws.

A deaf man who cannot speak runs from the scene of an accidental killing and is befriended by Stacey, who teaches him to communicate

Trampas makes a side trip to a Wyoming town to visit an old friend, only to learn upon his arrival that the man has been murdered.

A white girl is caught with her adoptive Arapaho parents stealing Shiloh cattle. She stays at Shiloh while the authorities try to find her white parents. She wants to return to the Arapaho but is forced to learn to live in the white world.

The Virginian is arrested and tried for murder when he investigates the disappearance of cattle.

A bitter widow revives a 25 year old feud when she learns the identity of Shiloh's new owner.