After stopping in the town of Jump-Up to see an old girlfriend, Tate is cheated in a card game by a gambler, and then framed by town boss John Timothy Driscoll and his son for killing the man, and forced into a hard labor camp.

After being mauled by a cunning wolf he has been tracking, and then robbed of his possessions by a stranger, MacKenzie is taken in by a homesteader and her son. The wolf, however, is still at large and MacKenzie is determined to kill him.

The Virginian challenges a sophisticated outlaw who controls a frightened community.

Mackenzie faces bad weather, rough terrain, Indians and cavalrymen when he pursues a man he thinks deserted his regiment.

Tate, on leave from Shiloh, discovers that building a barbed wire fence for a widower rancher and his children may involve more than stringing wire and sinking posts.

Mackenzie tends to a young woman injured in a fall from a horse, only to have a cowboy arrive and claim she is wanted for murder.

The Virginian seeks the identity of the person responsible for the mysterious killing of a widow's herd of cattle.

In nearly abandoned Spencer Flats, Trampas is held by Della and Annie Spencer, who accuse him of being outlaw Deke Slaughter, though their handyman is not so convinced. Then the real Slaughter rides into the town, claiming to be a sheriff.

Tate rescues a deaf Indian boy from a posse, then comes to his defense when a kangaroo court seems determined to convict the lad of homicide.

A trip to buy land for grazing puts the Virginian in the middle of a murder mystery involving a Senate hopeful, his ambitious wife, and hard drinking brother.

A jealous man who admits to killing his sister's alleged attacker, a Shiloh employee, recuperates from injuries at the ranch, but his sibling's romance with Mackenzie causes anger to resurface.

Aboard a train headed for a Western town, Trampas meets a girl and her ailing father who are tracking down a lead on their missing mother and wife.

MacKenzie is in New Mexico to buy cattle when he meets a female New York writer who takes an interest in the local Comancheros who are hated locally and especially by the Sheriff. Her story results in her kidnapping and trouble for all.

At the same time the Colonel's niece is visiting from England, Trampas is one of the suspects in the killing of a fellow ranch hand based on his custom gun. Trampas believes four brothers killed their cousin but how can he prove it?

After locating supposedly lost Shiloh cattle in the possession of an unfriendly commune, the Virginian is asked for help by two women members being forced into a multiple marriage.

MacKenzie is injured saving Tate on a cattle drive. Tate takes him to Concho for help only to find the doctor there is in jail and to hang the next day. Tate is able to secure his release but finds that it comes with some high costs.

Accused of murdering a gold mine owner over a poker debt, Trampas finds himself in the capable hands of a woman lawyer. The law seems primarily interested in wrapping up the trial as quickly as possible so they can go fishing.

A group of German immigrants is repeatedly threatened by night riders who want them out due to prejudice. Tate becomes involved after the daughter of the leader of the immigrants mistakes him for the gunman they hired to protect them.

Two brothers accuse the Virginian of being the man who widowed their mother, and a judge seems eager to agree with them.

A man Mackenzie rescues from a lynch mob becomes an unexpected hero when kidnappers strike aboard the train they are all riding.

A captain's plan to buy back his lost riverboat from lucky gambler Trampas falls into disarray when a train robbery gang commandeers the vessel in question for a getaway.

The Virginian rescues a woman and renews an old friendship with her, only to discover she has been dishonest with him when outlaws attack the stage they are riding.

A Mexican girl's indecision over whether to marry Trampas' friend or her father's aide threatens to touch off a gunfight between the two.

Col. Mackenzie, new owner of the Shiloh Ranch, becomes embroiled in a controversy with the cattlemen's association when he insists on investigating the hanging of an accused cattle rustler.