Despite everyone being on high alert due to the threats against Jens Bols, they are unable to prevent another attack on him. When Bols leaves his house in the morning, his car is blown up. Miraculously, he survives the attack. Eva and Wolfs are assigned to protect him. However, Wolfs is completely distracted by his daughter's situation. When Wolfs is assigned to investigate a counterfeiter, he sees his chance. Meanwhile, Mechels orders Eva to take Bols to a safe house in Amsterdam. Neither of them wants to go, but given the danger, they accept their fate. At the safe house, Eva sees a special police report on TV and tries to reach Wolfs, who turns out to be busy with other matters.

Contaminated pills are appearing in Maastricht's nightlife scene. It proves fatal for one girl. After studying surveillance footage, the dealer is fortunately caught quickly, but he refuses to say anything. Because there is insufficient evidence, Bols has to let him go, after which Wolfs and Eva keep an eye on the boy. This quickly leads them to the place where the pills are produced. Mechels forces Wolfs to improve his relationship with Bols and go out for dinner together. When a failed attempt is made on Bols' life during that dinner, it becomes clear that he has been under threat for some time. Most likely from the gang of jewel thieves that Wolfs and Eva caught earlier. Fleur's situation in prison is deteriorating by the day and the prison management refuses to improve her situation. Wolfs tries everything, but even Mechels and Bols are unable to help him. He becomes increasingly frustrated and decides to take matters into his own hands.

It is evening and a number of students from the Maastricht theater school are rehearsing for a play. Tempers and emotions run so high that a few actors run outside crying and arguing. One of them is found dead in the Maas river in the morning. Wolfs and Eva investigate and encounter a stubborn director. The man is a well-known, up-and-coming talent who does not hesitate to push his actors to the limit, using drugs if necessary. It is clear to Wolfs and Eva that this experiment proved fatal for the young man. However, this proves difficult to prove. Fleur is having a hard time in prison. She is threatened by women who have been sent to prison by Wolfs and Eva. There is even an attempt to murder her. Wolfs does what he can, but the prison management does not seem to take it very seriously.

Wolfs and Eva are confronted with ruthless criminals who have their sights set on a jewelry store. They take the sick daughter of an employee hostage, who lets them in and gives them access to the safe. The men make off with a large amount of expensive jewelry. But thanks to Wolfs and Eva's alertness, they manage to catch one of the perpetrators before he can escape via the airport. They interrogate the man, Serge, but he doesn't budge and even laughs at them. The next day, it becomes clear why. His accomplices have kidnapped the sick girl again during the night and threaten to kill her if Serge is not released that same day. While everyone is searching for the girl's whereabouts, Wolfs and Eva have no choice but to let Serge go. Together with Mechels and Bols, they devise a daring plan to find the girl and recapture Serge. Meanwhile, Marion and Romeo are dealing with a foundling who was discovered at the church. Further investigation reveals that this is not the first time this has happened.

A councilman gets a rough time when he fails to arrange extra funding at a meeting of the local soccer club. As a result, the soccer club loses its fields and has to close down. A journalist on the scene wants to know what is going on and whether the councilman is engaging in cronyism. The next morning, the man is found beaten to death in front of his home. Everyone is convinced that it is an act of revenge by supporters. Then the rumor mill starts up and the question arises whether there is more to it than that. Did the councilor indeed favor business associates in municipal affairs and did he perhaps fall victim to an angry competitor? Romeo and Marion are confronted with nuisance caused by young drug dealers.

Wolfs and Eva are faced with a very unusual case. In a beautiful large house where former students from Delft have returned to live together after their retirement, one of the residents is shot dead in his room. The strange thing is that all the other residents were sitting together at the table at the time of the murder. So they couldn't have done it. There is a trail leading to the garden, but the gardener who was working at the time did not see anything unusual. Wolfs and Eva rack their brains trying to figure out who could have committed the murder and, more importantly, how. Romeo and Marion are searching for a missing Belgian boy. His very Christian mother is extremely worried, because her son is not used to wandering around alone in a big city like Maastricht.

Wolfs goes out with an old college friend who tells him that he is terminally ill and plans to end his life soon. He asks his old buddy Wolfs to inform his wife when he is gone. Wolfs tries to change his mind during the long evening, but to no avail. The next day, his friend's car is found abandoned near the Maas River. Wolfs fears suicide and takes his friend's wife in. But what was the car doing near the body of a known criminal found that same morning? Coincidence or is there more to it? Romeo and Marion throw themselves into a series of thefts in a nursing home. Not an easy case, because anyone could have done it. However, a conversation with the director sheds new light on the case.

During the transport of a notorious criminal to court, a spectacular rescue operation takes place. The bus transporting him is blocked, and the man manages to escape. In addition to the dangerous criminal, Wijnand de Jonge, the artist and serial killer whom Wolfs and Eva had previously arrested, also escapes. A massive manhunt for the escaped prisoners ensues. Romeo and Marion spot Wijnand in a luxury car, but lose him. Then Wolfs and Eva take up the chase, but they too lose sight of him at a construction site. Then Wijnand contacts them. He claims not to have committed the earlier murders and is now looking for the real perpetrator himself. When Marion and Romeo investigate a complaint from a shepherd about a stray dog, they arrive at a veterinarian's office. Romeo is suspicious because the curtains are closed during the day. When the front door opens, they have to decide what to do in a split second.

A well-known designer from Maastricht is found dead in her studio. This is strange, because her husband drove her to the airport that evening for a flight to Milan. Wolfs, Eva, Marion, and Romeo arrive at the scene when the cause of death cannot be immediately determined. Only after an autopsy does it become clear that she was poisoned with sarin gas. Her husband suspects his brother-in-law and is furious with Marion because he has already reported the man to her twice. The brother turns out to be a schizophrenic man who has often threatened to harm his sister because he is convinced that she used her designs to tell the world about him. When it turns out that he has the components needed to make sarin in his home, the question remains whether or not he is the perpetrator. Marion is so upset by her husband's accusations that when she is called to a domestic violence case, she acts more harshly than she wants to. This subsequently results in a complaint.

The girlfriend and model of a well-known Maastricht artist is found dead in her parents' bathtub, with a plastic bag over her head. Everything points to suicide, but her father, a former police officer, is convinced it is murder. The case takes Wolfs and Eva into a world of art, big egos, jealousy, and lots of alcohol and drugs. Then they discover that the dead girl in the bathtub is not the only model who has died under suspicious circumstances. Are they dealing with a serial killer? Marion meets an old school friend at the police station. They hit it off right away, until she hears what he's there to report: aliens have abducted his favorite cow. Laughingly, she promises to take a look at the farm, where Romeo loses count among the cows and Marion thinks there's more to it than that.

On an industrial estate, a man witnesses a brutally executed professional robbery at a cash office, involving heavy weapons and leaving one person dead. Wolfs and Eva quickly arrive on the scene and a wild chase ensues. After a fierce firefight, the perpetrators escape and Wolfs and Eva discover that the dead young man was previously involved in a clumsy, failed robbery attempt. Since this does not fit in with this professional robbery, they have to pull out all the stops to find out who the boy robbed the cash office with and how they got their heavy weapons. Two brothers from the criminal underworld who hate each other's guts meet for the first time since their quarrel at their mother's funeral. The family is afraid that this will get seriously out of hand. Romeo and Marion go to check it out.