Eva is furious at Wolfs and Mechels and calls herself sick. But the case comes to her when David Boesmeer senses danger. He has been warned and all the mafia members have disappeared from the radar. Only Eva still has a clue as to where the mafiosi are. But will she share it with the team she is so angry with?

A woman kills her husband at night while he is sleeping. It turns out she has too many antidepressants in her blood. The woman is undergoing treatment to cope with the loss of her only child. Her therapist is not a licensed psychologist and is therefore not allowed to prescribe medication. It turns out she is not the only one for whom he has become a kind of guru. Marion and Romeo once again have to deal with Joe's short temper, which gets him into trouble. Eva notices that Wolfs and Mechels are keeping her out of an investigation. Wolfs feels compelled to inform her. This does not remain without consequences.

When Wolfs and Eva hear that a man has disappeared from a village near Maastricht, they quickly link it to a cold case investigation. Years ago, a child was raped and murdered in that village. They are now trying to solve that case with a DNA test on all male residents. What does the man's disappearance have to do with that case? Marion and Romeo are dealing with an escalating neighbor dispute. Sophia Arletti, an Italian detective, shows up at the station. She wants Wolfs to assist her with an investigation.

The financial controller of a charity organization crashes her car and dies on the way to the hospital. A simple accident, until it turns out that she has a lethal amount of medication in her blood. Wolfs and Eva discover that the charity is in financial trouble. It also turns out that the accounts are not in order. Romeo, who is finally freed from his desk duties, and Marion have to deal with a gang of pickpockets. Wolfs makes a discovery in the investigation into the mafia.

An amber alert is issued and soon a witness reports an incident at a gas station. He says that a girl had asked to use his phone to make a call. It turns out that she had called the children's helpline to warn that a girl was about to be kidnapped. The Amber Alert is withdrawn when it turns out that the girl has run away from home. But Wolfs and Eva can't get the call to the children's helpline out of their minds. Especially when another call is made to the helpline and a young girl disappears. Joe and Marion are confronted with a mentally disturbed young woman. They offer help, but how can they actually help her?

A car is found in a parking lot with the body of a Polish man inside. The case immediately reminds Eva and Wolfs of an earlier, unsolved murder with the same modus operandi. A burglary in the neighborhood, in which a gun has disappeared, seems to lead to a breakthrough in both cases. But the family that was burglarized is not exactly your average family. While Romeo grits his teeth behind his desk, Joe's boisterous approach causes problems.

Wolfs and Eva are called to the scene of a young man's brutally mutilated body. It soon becomes clear that some time ago, while driving far too fast, he caused a traffic accident in which a mother and child were killed. When a witness reports seeing the husband near the scene of the crime, it appears to be a revenge killing. Marion tries to mentor intern Joe, but that proves to be easier said than done.

A familiar face shows up at the police station. Singer Jan Smit is in town for a performance at the Muziekfeest op het Vrijthof music festival. He wants to spend a day shadowing Wolfs and Eva to prepare for a role he will be playing in a police film. They are called to an accident at a stud farm. But is it really an accident? Marion has to deal with an enthusiastic intern from the police academy: Joe Verwaayen.

A driver comes to report his stolen truck, which has been found with a dead Romanian prostitute next to it. Wolfs and Eva have to find out why the empty truck was targeted for theft. Romeo is told his punishment for illegally using the police computer.

The agency is fully committed to hunting down Tony Verwoerd. Forensic evidence on the body of the tortured woman leads to Liège. But where in that city can Tony be found? Will they find him in time to prevent a fatal outcome?

The agency is in shock over the attack on Wolfs, Eva, and public prosecutor Jens Bols. The National Criminal Investigation Department takes over the investigation into the attack and the leak at the agency and proceeds energetically. Romeo is suspended and Marion comes under the scrutiny of the National Criminal Investigation Department. Is she the leak they are looking for? Wolfs is assigned a case: a young woman has been fished out of the Maas. She has been severely beaten and tortured.