The team attempts to apprehend a notorious gang of drug runners through targeted traffic checks. Meanwhile, Eva tries to find out what happened to the stolen money through Rebecca, Luca's girlfriend. But she is not cooperating. Then there seems to be a breakthrough; a girl has spent money from the suitcase in an expensive boutique. She matches Rebecca's description. They search her house and find more money from the suitcase. The case seems to be closed, but then Eva makes a gruesome discovery.

During orientation week for new students, a girl reports her friend missing. When her bag is found on the street, Eva and Wolfs start looking for her. They soon discover that on the night she disappeared, she went off with a boy while drunk. The boy claims to have left her alive in a park. Meanwhile, Romeo and Marion try to get a homeless man with mental health issues off the streets. Eva finally makes a breakthrough in her investigation into the missing money, and Wolfs also makes a discovery.

After rudely arresting a man for mild verbal abuse, rookie Esmee is run over by a car and remains in coma. The culprit gets away and murders a squatting junkie, presumably just to cover his tracks. The only trace is a prepaid cellphone, but he's hard to identify for audio shopkeeper Jonkers. Romeo and partner are rudely kept away from Esmee's sickbed by her bitching mother, as as is her father, neighboring city cop Serge van Rooy, who was finally getting to know her.

During the grape harvest at a Maastricht winery, one of the pickers is found murdered. Eva and Wolfs investigate her death and quickly conclude that the girl was not well-liked by everyone in the picking team. Esmee and Romeo encounter a group of wayward youths who are exploiting younger children. Eva makes a discovery in her search for the missing money.

During the wedding reception—a boat trip on the Maas—the bride's father is murdered. It soon becomes clear to Wolfs and Eva that the two families do not get along. And that the murderer must still be on board. The case affects Eva more deeply than she is willing to admit. With Joes' help, she makes a drastic decision.

Wolfs and Eva investigate the death of an elderly woman. She was stabbed on her farm. Her husband has dementia and was found with the murder weapon in his hand. It seems like a family tragedy, but Wolfs and Eva discover that there is more to it than that. Marion, Romeo, and Esmee have their hands full with a quarreling ex-couple. Fleur is going to live with her mother in Barcelona.

Wolfs and Eva are confronted with a missing asset manager who claims to have lost a significant amount of his clients' money during the crisis. Did his clients seek retribution, or did he abscond with their funds? Esmee experiences physical violence for the first time when a man loses control in a computer store. Senseless violence, or is there more to it? Eva suspects that Luca may have had an accomplice when he went to get the money out of the suitcase.

At a care farm, the owners' nightmare becomes reality. The body of Melcher, a boy with Down syndrome, is found in the barn. Eva and Wolfs must find out what happened, which is not easy with the unusual witnesses they have at their disposal. Marion does not trust a move out of her neighborhood. She goes after it with Esmee. Eva investigates the missing money from the briefcase; she must and will prove that Wolfs had nothing to do with it.

Eva and Wolfs investigate the murder of a young man who was severely tortured before his death. The trail quickly leads to the coffee shop where he worked. But the owner is uncooperative, and the boy's parents are also withholding information. Romeo is assigned to work with a new colleague, Esmee. They are confronted with a series of bag snatchings. After the attack on Pension de Ponti, Wolfs and Eva have been given temporary accommodation in a hotel. Fleur has another plan: she asks her father if he would like to live with her. Eva befriends Joes, a bartender at the hotel.

The entire team is busy conducting a relentless manhunt for Daan de Vos. But Daan appears to have many more tricks up his sleeve, and it remains to be seen whether they will be able to catch him.