Cesare has a startling revelation; Lucrezia falls for a new suitor; Cesare cannot extract a confession; the assassin strikes.

Alexander prepares to end his fast with a celebration; Della Rovere's assassin becomes the Pope's taster; Lucrezia's lover proposes; Cesare makes a decision.

Juan tries to spin his combat injury as proof of his valor; Lucrezia takes a lover; Della Rovere recruits a young friar.

Juan returns from Spain; Alexander plans to lay siege to Sforza's castle; Lucrezia scuttles a marriage scheme.

Alexander begins a Lenten fast after fearing a sign from God; Cesare tries to prove his worth; the Pope pressures Lucrezia into another marriage.

The Pope demands allegiance from Catherina Sforza; Alexander hears Savonarola while in disguise in Florence; Della Rovere attempts recruitment.

Cesare recruits mercenaries to exact revenge on French troops; the pope forges strategic alliances; Lucrezia joins Giulia, who strives to aid the poor.

Alexander VI refuses to allow a Catholic burial for Paolo; Lucrezia embarks on a hunger strike; the French army heads to Rome; Della Rovere sneaks into the city.

The father of Lucrezia's child travels to meet her in Rome; the Pope's lovers take him on a tour of Rome's indigent.

Pope Alexander VI takes a new lover; a cache of ancient artifacts is discovered; Cesare and Juan's rivalry spills into the streets; Lucrezia tends her newborn child; Della Rovere escapes an assassination attempt.