Zahra is housebound by a rare condition, but new prosthetics may be her ticket to freedom. Mahogany's leg weighs nearly 100 pounds due to lymphedema. Joseph was born without a jaw but won't let it stop him.

There are only two foods that won't send Caroline into anaphylaxis; touching almost anything causes Ariana's butterfly skin to blister and tear; Aleazia's cystic hygroma caused his jaw and tongue to swell, permanently freezing his mouth open.

An allergic reaction left Kirtus with vitiligo, alopecia, and bone loss. An upcoming surgery could change his life. Portia's rare skin condition may exist in fewer than 25 people worldwide. Dani lost all four limbs, and now she fights to walk unassisted.

Lukas has Parry-Romberg Syndrome, causing half his face to shrink inward. Stefani's rare muscular dystrophy leaves her dependent on her mother but craving independence. Ellie says steroid withdrawal left her with lizard skin and seeks a cure.

Tiffany has progeria, a condition that causes her to age rapidly - yet she's already outlived her life expectancy. Single dad Ryan was born with Arthrogryposis, leaving his arms and legs fused. 

At just 18 years old, Loren was involved in a catastrophic forklift accident. To save his life, doctors cut him in half. Sofia was an active 29-year-old when her heart went into end-stage failure. Now she must be plugged-in to stay alive.