Pastor Juan's love of food made him overweight, but it has never been a problem until recently, since he's gotten too big to preach and sing to his congregation. If Juan is to help others, he must first help himself by curbing his earthly appetite. 

Deshaun takes being protective of his mom to the next level. He's over 700 pounds and won't leave his mother's apartment. Dr. Now and Dr. Paradise might be able to get him to leave the bedroom, but will Deshaun ever make it to Houston? 

At 6'3" and over 700 pounds, Jacky has barely had a chance to live. She's never fit in anywhere and has always felt out of place. Now that her parents have passed, she has a fresh chance to discover the world anew, but first she's got 500 pounds to lose. 

Gary doesn't leave the bed anymore. He has his mom and a bevy of caretakers to get him what he needs, but his life is slipping away from him. He is so overweight that just getting to Houston may be out of the question if he can't stop eating. 

Karen has gotten so out of control with her eating that she's developed a fear of leaving the house and interacting with the world at her size. She needs Dr. Now's help, but can Karen ever qualify for weight loss surgery if she won't leave the house? 

Krystal has never let her weight get in the way, but the truth is her weight has really started getting in the way. She has the husband of her dreams who supports her unconditionally, but to have a happy future with him she has to get weight loss surgery.  

Jonathan had his dream job, and he ate himself out of it. Once an EMT first responder, now he rarely leaves the room. His wife works full time to pay their bills, and Jonathan must break the cycle of eating if he wants to keep his wife and his life.