Tamy faces a tough choice when her husband wants her back but only if she moves away from Houston and Dr. Now's program. Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.

At over 600-lbs each, Vianey and Allen are in a co-dependent relationship based on a shared love of food. Can they conquer their food addiction together?

At over 600-lbs, Angie is trying to get to Houston to see Dr. Now and get life-saving weight-loss surgery. But a family conflict proves to be an obstacle.

With severe lymphedema Mercedes can barely stand, and her family helps her care for her young kids. To successfully lose weight she must confront her past trauma.

Having spent the last two years in his bed due to his weight, Cillas' food addiction prevents him from being there for his fiancée and her three daughters.

Mother of four LaShanta has been bed-bound for two years, and she relies on her kids to keep her cleaned and fed; her last chance to break the cycle of food addiction is to join Dr. Now's program, but it will take a village to get her out the door.

When Angela's family is unable to accompany her on her weight-loss journey to Texas, she is unsure what to do; at the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

When Annjeanette was nine, a campaign was established to send her to fat camp; she hated that her weight had become a source of public shame and she has struggled to overcome her food addiction; now, she must change her habits to save her life

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now; her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead. Aaron must learn to care for himself to avoid eating himself to death.

Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Despite moving to Houston with the solid support of her boyfriend, Aaron, and her cousin, Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian; when Christian decides he's had enough and leaves Maja high and dry, she discovers that the only person she can count on is herself.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Robin and her brother Chris are both obese and already lost a sibling to obesity; they plan to visit Dr. Now together when Chris suffers a stroke and can't go; Chris' son Garrett, already 600 pounds at age 20, is game to join the journey.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

With a sneak peek at the new season - Alicia is struggling with a lifelong food addiction that is causing strain with her longtime boyfriend, Tim; she must find help to change her ways or risk losing him forever.