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The lives of physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper are shaken up when an attractive young aspiring actress from Omaha, Nebraska named Penny moves into the apartment across the hall from theirs. Leonard begins to become hopelessly enamored of Penny, while she feels only platonic affection for him; as a result, she finds herself putting up with his closest and ever-present friends: his roommate, Sheldon, who appears borderline obsessive-compulsive; engineering whiz Howard Wolowitz, a desperately sex-crazed mama's boy who thinks that his 1960s-style clothing and hairstyle give him an air of cool hipness; and Dr. Rajesh "Raj" Koothrappali, who will not speak to her as he is too shy to talk to women (a case of selective mutism), unless intoxicated in which case he becomes a smooth talking yet highly overly aggressive womanizing flirt.
When Leonard asks Penny out on a date and she says yes, they each seek the "wisdom" of reluctant advisor.
When Penny learns that Leonard doesn't celebrate birthdays, she attempts to throw him a surprise party, but is sidetracked by Sheldon who unexpectedly gets to live out one of his greatest fantasies at an electronics store.
When Leonard, Wolowitz, and Koothrappali all become smitten with Sheldon's twin sister, Leonard devises a plan to eliminate his rivals, however, it backfires when Sheldon declares he will decide whom his sister dates.
When Leonard and the guys buy a time machine prop from a classic 1960 movie, its arrival creates problems for Penny and she tells the boys that their obsession with comics and toys is "pathetic".
Since Sheldon's only focus is to prove his mental superiority while preparing for the Physics Bowl, the guys kick him off the team and enlist his nemesis Leslie Winkle.
When Leonard and Sheldon meet a 15-year-old physics prodigy, Sheldon is distraught that this boy genius is younger and smarter, so in an attempt to restore his sense of purpose, the boys come up with a solution to derail Dennis' research.
When Sheldon gets sick, Leonard and the boys know what's in store and avoid him like the plague, leaving an unsuspecting Penny to nurse the world's worst patient back to health.
After hearing Penny sing, Leonard lies to avoid seeing her perform, but Sheldon takes it one step further with a more elaborate lie that leads to the appearance of his non-existent cousin.
When Sheldon and Leonard are invited to present their joint findings at a physics conference, Sheldon refuses, and Penny steps in to mediate, only deepening the rift between the two best friends.
Koothrappali is overwhelmed after his parents arrange a blind date, but he discovers he actually can talk to the opposite sex after a few drinks; however, complications set in when his beautiful date is more interested in Sheldon.
When Wolowitz seduces Penny's friend and takes over her apartment, Penny sleeps on Leonard and Sheldon's couch. With Wolowitz preoccupied, the guys discover they are without a fourth member of their group and in desperation, they ask Penny to join their Halo team.
Leonard, Sheldon, Wolowitz and Koothrappali undertake a challenging and risky experiment-attending the Halloween party being thrown by their hot neighbor, Penny.
After sensing his pursuit of Penny isn't going anywhere, Leonard agrees to an unexpected sexual encounter with fellow scientist Leslie Winkle.
When Sheldon gets fired, he explores life beyond physics, but his initial thrill of shopping with Penny devolves over time to him weaving ponchos as a shut-in, forcing Leonard to call on Sheldon's mother.
Leonard is bummed to learn that his crush, Penny, is seeing someone, so encouraged by his friends and fellow scientists, Leonard actually summons the nerve to ask a woman out on a date.
Leonard volunteers to sign for a package, hoping to make a good impression on Penny. When he enlists the help of his obsessive-compulsive roommate, Sheldon, his attempt at chivalry goes horribly awry.
Is a comedy about brilliant physicists, Leonard and Sheldon, who are the kind of "beautiful minds" that understand how the universe works. But none of that genius helps them interact with people, especially women. All this begins to change when a free-spirited beauty named Penny moves in next door. Sheldon, Leonard's roommate, is quite content spending his nights playing Klingon Boggle with their socially dysfunctional friends, fellow Cal Tech scientists Wolowitz and Koothrappali. However, Leonard sees in Penny a whole new universe of possibilities... including love.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.
Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.
Penny regrets her sleeping with Raj and has become very good friends with Leonard, Leonard breaks up with Priya, Amy pushes Sheldon in their relationship eventually becoming boyfriend and girlfriend, Penny and the other women become a clique of their own, Howard prepares for his wedding and going into space to the International Space Station and Leonard asks Penny out as they begin "Leonard and Penny 2.0".
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.
Penny throws herself at Leonard after he returns from three months at the North Pole and they begin a relationship, Penny and Sheldon start a quirky friendship though she can still annoy him, Howard begins to date Bernadette Rostenkowski and Sheldon meets Amy Farrah Fowler.
Leonard and Penny's relationship takes a turn for the worse when they break up, but is quickly resolved. Soon their relationship progresses into a stronger friendship than before, while Sheldon and Penny's friendship slowly begins.
The lives of physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper are shaken up when an attractive young aspiring actress from Omaha, Nebraska named Penny moves into the apartment across the hall from theirs. Leonard begins to become hopelessly enamored of Penny, while she feels only platonic affection for him; as a result, she finds herself putting up with his closest and ever-present friends: his roommate, Sheldon, who appears borderline obsessive-compulsive; engineering whiz Howard Wolowitz, a desperately sex-crazed mama's boy who thinks that his 1960s-style clothing and hairstyle give him an air of cool hipness; and Dr. Rajesh "Raj" Koothrappali, who will not speak to her as he is too shy to talk to women (a case of selective mutism), unless intoxicated in which case he becomes a smooth talking yet highly overly aggressive womanizing flirt.
