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Amy and Sheldon's wedding provides Sheldon with the information he needs to make a breakthrough in his symmetrical string theory. Meanwhile, their friends pick up Sheldon and Amy's families from the airport, and Mark Hamill agrees to officiate at the ceremony.
When Sheldon learns that his mother won't attend his wedding unless he invites his brother, Georgie, he and Leonard travel to Texas to end a family feud. Also, the Wolowitz kids inadvertently infest Amy, Bernadette, Wolowitz and Koothrappali with pinkeye.
Sheldon goes to Vegas to win money for science. Also, Penny and Bernadette take Amy wedding dress shopping, but her terrible choice entangles them in a web of lies.
Sheldon's comic book store experiences changes when writer Neil Gaiman puts Stuart's store on the map. Also, Koothrappali takes credit for Penny's astronomical discovery, and friendships are threatened.
A brilliant but reclusive scientist, Doctor Wolcott, invites Sheldon to his cabin in the middle of nowhere, and Leonard, Raj and Howard go along for the trip. Also, Penny and Bernadette improvise after Amy doesn't like the tame bachelorette party they planned for her.
When Leonard learns Sheldon is the president of the tenants association, he decides to run against him. Also, Bernadette encourages Wolowitz and Koothrappali to find the owner of a drone after they find it in the backyard.
Penny gets the opportunity to host Bill Gates at work when his company wants to partner with her pharmaceutical company. Also, Leonard, Koothrappali and Wolowitz do everything in their power to meet him, while Sheldon thinks he is the victim of an April Fools prank.
Leonard jumps through hoops to help secure the perfect wedding venue for Sheldon and Amy. Also, Bernadette and Wolowitz have a hard time deciding who should stay at home with the kids and who should go back to work.
When Bernadette won't go into labor, all her friends try different tactics to get things started. Also, Wolowitz confronts Bernadette after Amy accidentally reveals she's already chosen their son's name.
When Sheldon petitions Wil Wheaton to appear on the new Professor Proton show, Wil offers a role to Amy instead. Also, Penny gets angry when she thinks the female protagonist in Leonard's novel is based on her.
Koothrappali finds himself in the middle of domestic drama when he learns the woman he's dating, Nell, has a very upset husband, Oliver. Also, when Sheldon rents his old room back for a quiet place to work, he drives Leonard crazy by being a model tenant.
When Sheldon kicks Amy out to work solo, she and Leonard bond during a series of science experiments. Also, Bert the geologist replaces Wolowitz in the band Footprints on the Moon, and Sheldon finds Penny a surprising source of scientific inspiration.
To discover who would be most qualified to be best man and maid of honor at their wedding, Sheldon and Amy subject their friends to a series of secret experiments. Also, Penny reveals her true feelings about Amy.
Sheldon and Wolowitz plan birthday celebrations for Amy and Halley, respectively. Also, Leonard receives a Christmas letter from his brother that causes him to spiral out about his own lack of accomplishments.
Sheldon and Amy try to eliminate stress from wedding planning by applying math to the process. Also, Koothrappali "breaks up" with Wolowitz after realizing his best friend is actually hurting his confidence.
Sheldon tries to teach the guys a lesson after they cut him out of a potentially valuable Bitcoin investment. Also, a seven-year-old video reveals a secret about Leonard and Penny's relationship.
Leonard and Wolowitz are furious after they learn Sheldon went to work with the military behind their backs. Also, while Bernadette is on bed rest, she asks Raj to do some digging when she suspects Ruchi is trying to steal her job.
Sheldon and Bert collaborate on a research project, despite Sheldon's embarrassment. Also, Penny and Bernadette coach Koothrappali on how to navigate his relationship with Ruchi.
Sheldon goes head-to-head with Wil Wheaton for the role of the new Professor Proton. Also, Penny steps in to take care of Halley when Bernadette and Wolowitz both wind up on bed rest.
Sheldon and Koothrappali confide in Bernadette when they can't handle Amy and Wolowitz working together. Also, Penny and Leonard learn new tactics for how to deal Sheldon from an unlikely source.
Howard and Sheldon bond when they drive to the desert to shoot off a model rocket. Also, when Leonard's mom, Beverly, finds a new best friend in Penny, it rubs Leonard the wrong way.
As Sheldon stresses about picking a wedding date, Amy tries to convince him he has a more laid-back side. Also, Koothrappali and Stuart compete to win the heart of Bernadette's new coworker, Ruchi.
Leonard angers the university – and the entire physics community – after he gives an embarrassing interview. Also, Amy and Bernadette bond over having to hide their success from Sheldon and Howard.
Amy gives Sheldon an answer to his proposal while Howard and Bernadette struggle with some unexpected news.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.
Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.
Penny regrets her sleeping with Raj and has become very good friends with Leonard, Leonard breaks up with Priya, Amy pushes Sheldon in their relationship eventually becoming boyfriend and girlfriend, Penny and the other women become a clique of their own, Howard prepares for his wedding and going into space to the International Space Station and Leonard asks Penny out as they begin "Leonard and Penny 2.0".
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.
Penny throws herself at Leonard after he returns from three months at the North Pole and they begin a relationship, Penny and Sheldon start a quirky friendship though she can still annoy him, Howard begins to date Bernadette Rostenkowski and Sheldon meets Amy Farrah Fowler.
Leonard and Penny's relationship takes a turn for the worse when they break up, but is quickly resolved. Soon their relationship progresses into a stronger friendship than before, while Sheldon and Penny's friendship slowly begins.
The lives of physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper are shaken up when an attractive young aspiring actress from Omaha, Nebraska named Penny moves into the apartment across the hall from theirs. Leonard begins to become hopelessly enamored of Penny, while she feels only platonic affection for him; as a result, she finds herself putting up with his closest and ever-present friends: his roommate, Sheldon, who appears borderline obsessive-compulsive; engineering whiz Howard Wolowitz, a desperately sex-crazed mama's boy who thinks that his 1960s-style clothing and hairstyle give him an air of cool hipness; and Dr. Rajesh "Raj" Koothrappali, who will not speak to her as he is too shy to talk to women (a case of selective mutism), unless intoxicated in which case he becomes a smooth talking yet highly overly aggressive womanizing flirt.
