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Chaos ensues when Leonard's recently divorced parents, Alfred and Beverly, and Sheldon's devoutly religious mother, Mary, come to town. Also, Wolowitz and Koothrappali think the government is out to get them when they are contacted about their guidance system.
Sheldon hires Stuart to spend the day with Amy when he'd rather go to a movie screening. Also, Leonard's mother, Beverly, comes to town and Penny struggles to make a connection with her.
The gang goes to a wine bar and runs into Penny's old boyfriend, Zack. Also, Bernadette gets stuck spending the evening with Sheldon when she can't go wine tasting with the group, and things don't go as planned when Koothrappali introduces his new girlfriend, Claire.
Everyone must choose sides when a small argument between Leonard and Sheldon erupts into a heated fight during a group get-together.
Sheldon spills a secret of Leonard's when the two take a weekend cabin trip with Penny and Amy. Also, when Koothrappali goes overboard with pregnancy gifts, Wolowitz and Bernadette must draw the line.
Amy is shocked at a revelation from Sheldon after she buys him a new laptop. Also, Koothrappali sells out Leonard and Wolowitz after they lie to their wives in order to attend an early screening of a movie.
Leonard, Sheldon, and Wolowitz run into problems when they file for a patent for their infinite persistence gyroscope. Also, Penny, Amy and Bernadette give Koothrappali dating advice when Emily reaches out to him after their breakup.
After more than nine years together, the gang finally celebrates Sheldon's birthday, surprising him with a special guest.
When the gang finds out about Bernadette's pregnancy, they celebrate by singing karaoke. Also, Bernadette is concerned when Wolowitz freaks out over her pregnancy announcement, and Wolowitz is convinced he must make more money to provide for the baby.
Sheldon and Amy host a live Valentine's Day episode of Fun with Flags, Leonard and Penny grapple with getting older, Howard and Bernadette find a surprise in their hot tub and Raj is torn between Emily and the cute girl he met at the Comic Bookstore.
Sheldon's thrilled when his Meemaw comes to visit, but his excitement quickly fades when she butts heads with Amy. Also, Raj meets a new girl at the comic book store who makes him question his relationship with Emily.
After having to deal with a sick Sheldon, Leonard, Penny and the gang try to treat themselves to a Sheldon-free weekend.
Penny gets more than she bargained for when Leonard agrees to meet with a psychiatrist on her behalf. Also, Sheldon and Koothrappali collaborate on an astronomical discovery, and Wolowitz and Bernadette can't believe what they are feeling after Stuart moves out.
As the guys prepare to go to the premiere of the new Star Wars movie, Sheldon plans a special event for Amy's birthday. Also, Leonard, Wolowitz, and Koothrappali must decide who will take their extra Star Wars movie ticket.
Sheldon has a revelation when he realizes why a song was stuck in his head. Also, Amy invites Dave over for dinner despite their previously awkward date, and Wolowitz and Koothrappali become obsessed with a fan of their band, "Footprints on the Moon".
Sheldon and Amy try hanging out as friends when they spend Thanksgiving together at the aquarium. Also, Wolowitz reluctantly agrees to volunteer at the soup kitchen with Bernadette, Raj and Emily, and Penny discovers that Leonard knows more about her than she thought.
When Leonard, Penny and Bernadette learn that Amy is going out on a dinner date, the trio set out to spy on her and the guy. Meanwhile, Sheldon recruits Raj and Howard to find a woman for him, since they were responsible for getting Amy and him together.
While being interviewed for a documentary about Spock from "Star Trek", Sheldon struggles to suppress his emotions about his recent break-up with Amy. Also, Wolowitz and Bernadette butt heads over remodeling his childhood home.
In the midst of a nation-wide helium shortage, Sheldon and Leonard take desperate measures to get the supplies they need. Also, Penny and Bernadette download a dating app on Amy's phone to try and find her a new man.
The guys take a fencing lesson from Barry Kripke and Sheldon finds himself in an awkward position when Kripke expresses interest in Amy. Also, when Stuart struggles to get female customers at the Comic Book Store, Penny, Amy and Bernadette come by to help him out.
Sheldon learns of an impending change in his living arrangements and decides to revert back to 2003, a simpler time before he met Leonard and Penny. Also, Howard and Raj form a band to play at the Comic Book Store.
The guys surprise Leonard with a belated bachelor-party weekend in Mexico, but their plans hit a bump in the road when they get a flat tire on the way. Meanwhile, the girls lean on Penny to tell her unsuspecting family that she and Leonard eloped.
Leonard confronts the woman he kissed on the North Sea in an attempt to set Penny's mind at ease. Also, Sheldon films a special episode of "Fun with Flags" after his breakup with Amy, and Bernadette feels guilty about withholding a secret from Penny.
After driving to Vegas to get married, Penny struggles with Leonard's confession that he kissed another girl. Also, Sheldon doesn't know how to act after Amy pushes pause on their relationship.
Sheldon and Amy's relationship takes a step forward, Penny makes big decisions in her professional and person life, Raj tries to prosper in the dating world with his newfound ability to talk to women, and Howard treats Bernadette to a very special surprise for the anniversary of their first date.
Howard return from space and adjust to normal, married life on earth. Sheldon and Amy's unique relationship continues to progress, though at a slower pace than Amy wants. Leonard and Penny's relationship is business as usual, with Leonard once again proposing to Penny. Meanwhile, Raj finally meets a girl and enters a (somewhat) stable relationship, the demise of which leads to unexpected progress for Raj.
Penny regrets her sleeping with Raj and has become very good friends with Leonard, Leonard breaks up with Priya, Amy pushes Sheldon in their relationship eventually becoming boyfriend and girlfriend, Penny and the other women become a clique of their own, Howard prepares for his wedding and going into space to the International Space Station and Leonard asks Penny out as they begin "Leonard and Penny 2.0".
Sheldon begins a platonic relationship with Amy, Howard reconnects with Bernadette eventually asking her to marry him, Leonard begins to date Raj's sister Priya, Penny becomes friends with Amy and expresses regret at breaking up with Leonard.
Penny throws herself at Leonard after he returns from three months at the North Pole and they begin a relationship, Penny and Sheldon start a quirky friendship though she can still annoy him, Howard begins to date Bernadette Rostenkowski and Sheldon meets Amy Farrah Fowler.
Leonard and Penny's relationship takes a turn for the worse when they break up, but is quickly resolved. Soon their relationship progresses into a stronger friendship than before, while Sheldon and Penny's friendship slowly begins.
The lives of physicists Dr. Leonard Hofstadter and Dr. Sheldon Cooper are shaken up when an attractive young aspiring actress from Omaha, Nebraska named Penny moves into the apartment across the hall from theirs. Leonard begins to become hopelessly enamored of Penny, while she feels only platonic affection for him; as a result, she finds herself putting up with his closest and ever-present friends: his roommate, Sheldon, who appears borderline obsessive-compulsive; engineering whiz Howard Wolowitz, a desperately sex-crazed mama's boy who thinks that his 1960s-style clothing and hairstyle give him an air of cool hipness; and Dr. Rajesh "Raj" Koothrappali, who will not speak to her as he is too shy to talk to women (a case of selective mutism), unless intoxicated in which case he becomes a smooth talking yet highly overly aggressive womanizing flirt.